检验医学与临床2024，Vol.21Issue(7)：929-933,5.DOI:10.3969/j.issn.1672-9455.2024.07.014
GP1BA、PTGS1、LTC4S、ITGB3基因多态性检测指导阿司匹林使用
GP1BA,PTGS1,LTC4S and TGB3 gene polymorphism testing for guiding aspirin use
摘要
Abstract
Objective To retrospectively analyze the distribution of genotypes of aspirin drug-related genes in Baoji area of Shaanxi,and to definite the mutation rate of aspirin drug-related genes.Methods A total of 475 inpatients receiving aspirin treatment in the cardiologic medicine department of Baoji Municipal Hospital of Traditional Chinese Medicine from January 2022 to May 2023 were selected.The four genes related to aspi-rin drugs(GP1BA gene,PTGS1 gene,LTC4S gene,ITGB3 gene)were detected by the time-of-flight mass spectrometer,and then the gene polymorphism of the detection results was analyzed.Results The distribution frequency of each gene was in line with Hardy-Weinberg equilibrium rule,GP1BA c.482C＞T genotype distri-bution frequency CC＞CT＞TT,ITGB3 c.176T＞C genotype distribution TT＞TC＞CC,PTGS1 c.-842A＞G genotype distribution frequency AA＞AG＞GG,LTC4S c.-444A＞C genotype distribution AA＞AC＞CC.There was no statistically significant difference in genotype distribution between the different genders and a-ges.Conclusion Aspirin drug-related gene testing for the patients with aspirin drug treatment could provide the auxiliary guidance for clinicians to formulate the individualized treatment regimen for the patients,which has an important clinical value.关键词
基因多态性/阿司匹林/血小板膜糖蛋白Ⅰbα多肽基因/前列腺素内过氧化物合酶1基因/白三烯C4合酶基因/糖蛋白Ⅲa基因/个体化治疗Key words
gene polymorphism/aspirin/GP1BA gene/PTGS1 gene/LTC4Sgene/ITGB3 gene/individualized treatment分类
医药卫生引用本文复制引用
冯淳,姚杨,甄拴平,王慧,赵家骏,王华..GP1BA、PTGS1、LTC4S、ITGB3基因多态性检测指导阿司匹林使用[J].检验医学与临床,2024,21(7):929-933,5.基金项目
陕西省宝鸡市卫生健康委员会科研项目(2021-42). （2021-42）
