检验医学与临床2024，Vol.21Issue(7)：945-947,953,4.DOI:10.3969/j.issn.1672-9455.2024.07.017
盐酸齐拉西酮联合丙戊酸钠对双相Ⅰ型障碍躁狂发作患者PANSS评分及微炎症指标的影响
Effect of ziprasidone hydrochloride combined with sodium valproate on PANSS score and micro inflammatory indicators in patients with bipolar type Ⅰ manic episode
摘要
Abstract
Objective To explore the efficacy of combined treatment of sodium valproate and ziprasidone hydrochloride in the patients with bipolar disorder type Ⅰ(BP-Ⅰ)manic episode.Methods Ninety-two pa-tients with BP-Ⅰ manic episodes admitted and treated in this hospital from January 2022 to January 2023 were divided into control group and observation group by using the random number table method,46 cases in each group.The control group was treated with sodium valproate,while the observation group was treated with zi-prasidone hydrochloride on the basis of the control group.Both groups were treated for 8 weeks.The Bech-Rafaelsdn Mania Rating Scale(BRMS)score,Positive and Negative Symptom Scale(PANSS)score,micro in-flammatory markers levels and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the PANSS score and BRMS score in both groups were decreased(P＜0.05),more-over the scores in the observation group were lower the those in the control group(P＜0.05);after treat-ment,the levels of serum tumor necrosis factor-α,interleukin-1β and interleukin-1 after treatment in the two groups were decreased(P＜0.05),moreover the observation group was lower than those in the control group(P＜0.05);there was no statistically significant difference in the occurrence of adverse reactions between the two groups(P＞0.05).Conclusion The combination treatment of sodium valproate and ziprasidone hydrochloride in the patients with BP-Ⅰ manic episodes could reduce the degree of mild mania,improve the mental symptoms,regu-late the micro inflammatory indicators levels without increasing adverse reactions and with good safety.关键词
双相Ⅰ型障碍/躁狂/丙戊酸钠/盐酸齐拉西酮/炎症指标Key words
bipolar type Ⅰ disorder/mania/sodium valproate/zirasidone hydrochloride/inflam-matory indicators分类
医药卫生引用本文复制引用
钟伦淳,谢宇花,赖忠红,何海英..盐酸齐拉西酮联合丙戊酸钠对双相Ⅰ型障碍躁狂发作患者PANSS评分及微炎症指标的影响[J].检验医学与临床,2024,21(7):945-947,953,4.基金项目
江西省赣州市指导性科技计划项目(GZ2022ZSF292). （GZ2022ZSF292）
