检验医学与临床2024，Vol.21Issue(7)：948-953,6.DOI:10.3969/j.issn.1672-9455.2024.07.018
围绝经期女性外周血OSTF1、OPG/RANKL对骨质疏松症的预测价值
Predictive value of peripheral blood OSTF1,OPG/RANKL for osteoporosis in perimenopausal women
摘要
Abstract
Objective To explore the predictive value of peripheral blood osteoclast stimulatory factor 1(OSTF1),osteoprotegerin(OPG)/receptor activator of nuclear factor κB-ligand(RANKL)for osteoporosis in perimenopausal women.Methods A total of 165 patients with perimenopausal osteoporosis admitted and treated in Hebei Provincial Maternal and Child Healthcare Center from March 2021 to January 2023 were se-lected as the disease group,and 120 healthy volunteers of normal bone mineral density during perimenopausal period in the same time were included as the control group.The Pearson correlation was used to analyze the correlation between OSTF1,OPG/RANKL with bone mineral density.The base line data were collected.The univariate analysis and multivariate Logistic regression analysis were used to determine the influencing factors of osteoporosis,and the receiver operating characteristic(ROC)curve was used to determine the predictive value of peripheral blood OSTF1,OPG/RANKL for osteoporosis.Results The levels of serum OSTF1,RANKL in the disease group were significantly higher than those in the control group,while serum OPG level and OPG/RANKL were significantly lower than those in the control group(P＜0.05).The overall bone den-sity,lumbar spine bone density and T value in the disease group were significantly lower than those in the con-trol group(P＜0.05).Multivariate Logistic regression analysis results showed that OSTF1,OPG/RANKL,OPG,overall bone density,lumbar spine bone density,T value and RANKL were the influencing factors of os-teoporosis occurrence(P＜0.05).The ROC curve analysis results showed the area under the curve(AUC)of serum OSTF1 for predicting the occurrence of osteoporosis was 0.772(95％CI:0.705-0.843);which of OPG/RANKL was 0.616(95％CI:0.531-0.699);which of OSTF1 and OPG/RANKL combination was 0.906(95％CI:0.864-0.952).Conclusion Peripheral blood OSTF1,OPG/RANKL in the perimenopausal women are abnormally expressed,which could be applied in the prediction of osteoporosis,and they are worthy of further clinical research and promotion.关键词
围绝经期/骨质疏松症/护骨素/核因子-κB受体活化因子配基/破骨细胞刺激因子1Key words
perimenopause/osteoporosis/osteoprotegerin/receptor activator of nuclear factor kap-pa-B ligand/osteoclast stimulatory factor 1分类
医药卫生引用本文复制引用
薛国丽,李园,薛乔,赵英英..围绝经期女性外周血OSTF1、OPG/RANKL对骨质疏松症的预测价值[J].检验医学与临床,2024,21(7):948-953,6.基金项目
河北省卫生健康委员会医学科学研究项目(20231178). （20231178）
