检验医学与临床2024，Vol.21Issue(7)：954-957,962,5.DOI:10.3969/j.issn.1672-9455.2024.07.019
DCE-MRI、DWI联合检查在诊断三阴型乳腺癌中的价值
Value of DCE-MRI and DWI combined examination in diagnosing triple negative breast cancer
高伟 1黄杨 1李瑜珂1
作者信息
- 1. 河南省安阳市妇幼保健院放射科,河南安阳 455000
- 折叠
摘要
Abstract
Objective To explore the clinical value of dynamic contrast-enhanced magnetic resonance ima-ging(DCE-MRI)and diffusion weighted imaging(DWI)combined examination in the diagnosis of triple neg-ative breast cancer(TNBC).Methods A total of 130 patients with breast cancer admitted and treated in this hospital from April 2020 to February 2023 were selected and divided into the TNBC group and non-TNBC group according to the results of puncture biopsy and immunohistochemical results.DCE-MRI and DWI were performed in both groups.The diagnostic value of DCE-MRI and DWI combined examination in TNBC was analyzed.The DCE-MRI quantitative parameters[volume fraction(Ve),volume transfer constant(Ktrans)and rate constant(Kep)],semi quantitative parameters[contrast agent inflow concentration enhancement rate(W-in),contrast agent outflow concentration attenuation rate(W-out),contrast agent concentration peak time(TTP)],and the apparent diffusion coefficient(ADC value)of the two groups when DWI checking different diffusion sensitivity factors(b value)were compared between the two groups.Results The results of punc-ture biopsy and immunohistochemistry definitely diagnosed 27 cases in the TNBC group and 103 cases in the non-TNBC group.The differences of lesion type,T2 signal and enhancement type between the two groups were statistically significant(P＜0.05).The Ktrans and Kep levels in the TNBC group were higher than those in the non-TNBC group(P＜0.05),while the Ve,W-out levels were lower than those in the non-TNBC group(P＜0.05),TTP was shorter than that in the non-TNBC group;the ADC values of the TNBC group with b values as 800 s/mm2,1 000 s/mm2,and 1 500 s/mm2 were lower than those of the non-TNBC group(P＜0.05);DCE-MRI detected 20 cases of TNBC and 110 cases of non-TNBC;DWI detected 17 cases of TN-BC and 113 cases of non-TNBC;DCE-MRI+DWI detected 28 cases of TNBC and 102 cases of non-TNBC.The accuracy,sensitivity and negative predictive value of DCE-MRI+DWI examination in diagnosing TNBC were higher than those of the two examination methods alone(P＜0.05),and the missed diagnosis rate was lower than that of the two examination methods alone(P＜0.05).Conclusion DCE-MRI+DWI examination for di-agnosing TNBC could effectively improve the diagnostic accuracy,sensitivity and negative predictive value of TNBC,which providing a basis for the diagnosis and targeted intervention of TNBC.关键词
三阴型乳腺癌/动态增强磁共振/弥散加权成像/表观弥散系数/诊断Key words
triple negative breast cancer/dynamic contrast-enhanced magnetic resonance imaging/dif-fusion weighted imaging/apparent diffusion coefficient/diagnosis分类
医药卫生引用本文复制引用
高伟,黄杨,李瑜珂..DCE-MRI、DWI联合检查在诊断三阴型乳腺癌中的价值[J].检验医学与临床,2024,21(7):954-957,962,5.
