军事医学2024，Vol.48Issue(3)：236-240,5.DOI:10.7644/j.issn.1674-9960.2024.03.012
星形胶质细胞在放射性脑损伤中的研究进展
Pathology and therapeutic potential of astrocytes in radiation-induced brain injury
韩思缦 1陈怡霏 2沈东来 2王以政2
作者信息
- 1. 南华大学衡阳医学院,军事科学院军事医学研究院研究生协作培养基地,湖南衡阳 421001
- 2. 复旦大学附属华山医院老年临床疾病医学研究中心,上海 200040
- 折叠
摘要
Abstract
Radiation-induced brain injury is a severe brain injury caused by ionizing radiation to normal brain tissue.It is manifested as cognitive dysfunction,decreased learning and memory ability and can even lead to dementia.The treatment of existing drugs for radiation-induced brain injury are far from effective with poor prognosis.Ionizing radiation induces pathological activation of astrocytes,which aggravates the process of radiation-induced brain injury by inducing neuroin-flammation and destroying the blood-brain barrier.Here we review the physiological and pathological functions of astrocytes,then analyze the pathological changes and cellular mechanisms of astrocytes involved in radiation-induced brain injury.Furthermore,the therapeutic potential of astrocytes in radiation-induced brain injury is discussed,which is expected to provide reference for finding more approaches to radiation-induced brain injury and exploring new therapeutic targets and methods.关键词
放射性脑损伤/认知障碍/星形胶质细胞/神经炎症/血脑屏障Key words
radiation-induced brain injury/cognitive dysfunction/astrocyte/neuroinflammation/blood-brain barrier分类
医药卫生引用本文复制引用
韩思缦,陈怡霏,沈东来,王以政..星形胶质细胞在放射性脑损伤中的研究进展[J].军事医学,2024,48(3):236-240,5.
