摘要
Abstract
Objective To investigate the relationship between serum ischemia-modified albumin(IMA),hypersensitive C-reactive protein(hs-CRP)and pentraxin 3(PTX3)with the severity in the patients with a-cute myocardial infarction(AMI)and their predictive efficiency for the major adverse cardiovascular events(MACE)in the short term after percutaneous coronary intervention(PCI).Methods A total of 93 patients with AMI admitted and treated in this hospital from January 2021 to January 2023 were selected into the AMI group and 93 healthy subjects undergoing physical examination during the same period were selected as the healthy control group.Serum IMA,hs-CRP and PTX3 levels were compared between the two groups and a-mong the patients with different prognosis,and the correlation of serum IMA,hs-CRP and PTX3 with the number of coronary vascular lesion vessels,QRS score of electrocardiogram and KilliP grade as well as the predictive value for prognosis were analyzed.Results The levels of IMA,hs-CRP and PTX3 at admission in the AMI group were significantly higher than those in the healthy control group(P＜0.05).There were sta-tistically significant differences in serum IMA,hs CRP and PTX3 levels among the patients with different cor-onary vascular lesion vessels number,electrocardiogram QRS scores and KilliP grades(P＜0.05);the serum IMA,hs-CRP and PTX3 levels were positively correlated with the lesion vessels number,QRS score and Killip grade(P＜0.05).At 6 months after PCI,the AMI patients were divided into the MACE group with 20 cases and the non-MACE group with 73 cases according to whether MACE occurs or not.The serum IMA,hs-CRP and PTX3 levels on postoperative 1 d in the patients of the MACE group were higher than those in the non-MACE group(P＜0.05).The areas under the curve(AUC)of serum IMA,hs-CRP and PTX3 for predicting MACE occurrence after PCI were 0.707,0.792 and 0.782,respectively,and the optimal cut-off values were 95.44,21.74,3.27 ng/mL.AUC of combined prediction was 0.935(95％CI:0.864-0.975),which was grea-ter than that of the single prediction of each index(P＜0.05),the specificity was 85.00％and the sensitivity was 95.89％.Conclusion The serum IMA,Hs-CRP and PTX3 levels in the patients with AMI are abnormally increased,the 3 indicators are not only closely correlated with the severity of the disease,but also increase the risk of MACE occurrence after PCI.Their early combined detection could serve as the important biochemical marker for clinical assessment of the disease condition and prognosis judgment.关键词
急性心肌梗死/缺血修饰清蛋白/正五聚蛋白3/经皮冠状动脉介入/主要不良心血管事件Key words
acute myocardial infarction/ischemia-modified albumin/pentraxin 3/percutaneous coro-nary intervention/major adverse cardiovascular events分类
医药卫生
