临床肝胆病杂志2024，Vol.40Issue(4)：797-803,7.DOI:10.12449/JCH240425
乙型肝炎相关肝内胆管癌的发病机制
Pathogenesis of hepatitis B-associated intrahepatic cholangiocarcinoma
摘要
Abstract
Intrahepatic cholangiocarcinoma(ICC)is a type of primary liver cancer that accounts for about 10%—15%of the total cases,and its incidence and mortality rates tend to increase significantly around the world,especially in Asian countries.At present,radical liver resection is the only possible cure for ICC,but with a fairly high postoperative recurrence rate and a poorer prognosis than hepatocellular carcinoma.Therefore,it is urgently needed to further investigate the mechanisms of the development and progression of ICC and search for more effective treatment methods.Some epidemiological data suggest that chronic hepatitis B virus infection is one of the most important predisposing factors for ICC,yet little is known about its oncogenic effects.This article summarizes the epidemiological evidence that links the two diseases and briefly elaborates on the mechanisms of the development and progression of HBV-associated ICC,so as to help to gain a better understanding of the role of HBV in the development and progression of ICC.关键词
胆管上皮癌/乙型肝炎病毒/致癌作用Key words
Cholangiocarcinoma/Hepatitis B virus/Carcinogenesis引用本文复制引用
田奇玉,余建,黄罡..乙型肝炎相关肝内胆管癌的发病机制[J].临床肝胆病杂志,2024,40(4):797-803,7.基金项目
国家自然科学基金(82002458)National Natural Science Foundation of China(82002458) （82002458）
