临床肝胆病杂志2024，Vol.40Issue(4)：810-815,6.DOI:10.12449/JCH240427
氨基酸代谢在非酒精性脂肪性肝病中的作用机制
Mechanism of amino acid metabolism in nonalcoholic fatty liver disease
摘要
Abstract
Nonalcoholic fatty liver disease(NAFLD)is one of the most prevalent chronic liver diseases in the world,affecting about one quarter of the global population,and it is estimated that NAFLD will become the main indication for liver transplantation by 2030.NAFLD can lead to significant abnormalities in the levels of a variety of amino acids including branched-chain amino acids,thereby promoting the development and progression of NAFLD.These results suggest that in addition to glucose and lipid metabolism,amino acid metabolism also plays an important role in the progression of NAFLD.In order to systematically understand the role and mechanism of amino acid metabolism in NAFLD,this article reviews the research advances in amino acid metabolism in NAFLD.This article aims to explore the role and mechanism of amino acid metabolism in the progression of NAFLD,so as to provide ideas and a theoretical basis for clinical prevention and treatment.关键词
非酒精性脂肪性肝病/氨基酸类/代谢组学Key words
Non-alcoholic Fatty Liver Disease/Amino acids/Metabolomics引用本文复制引用
张慧,谭明,程胜桃,陈娟..氨基酸代谢在非酒精性脂肪性肝病中的作用机制[J].临床肝胆病杂志,2024,40(4):810-815,6.基金项目
国家自然科学基金面上项目(82273423) （82273423）
国家自然科学基金青年基金(82202501)General Project of National Natural Science Foundation of China(82273423) （82202501）
Youth Fund of National Natural Science Foundation of China(82202501) （82202501）
