临床肝胆病杂志2024，Vol.40Issue(4)：822-827,6.DOI:10.12449/JCH240429
Hedgehog信号通路在肝细胞癌中的作用及其与肿瘤微环境的关系
Role of the Hedgehog signaling pathway in hepatocellular carcinoma and its tumor microenvironment
摘要
Abstract
The Hedgehog(Hh)signaling pathway plays an important role in the development and progression of hepatocellular carcinoma and its tumor microenvironment,and abnormal activation of Hh signal can accelerate the growth of tumor.The crosstalk between the Hh signaling pathway and TME is closely associated with tumor growth and the formation of inhibitory tumor microenvironment.Evidence shows that inhibition of Hh signal plays an important role in inhibiting the growth of hepatocellular carcinoma.This article reviews the current research status of the role,mechanism,and potential therapeutic significance of abnormal activation of Hh signal in hepatocellular carcinoma and its tumor microenvironment,so as to provide new ideas for the treatment of hepatocellular carcinoma.关键词
癌,肝细胞/肿瘤微环境/Hedgehog信号通路Key words
Carcinoma,Hepatocellular/Tumor Microenvironment/Hedgehog Signaling Pathway引用本文复制引用
张晓华,冯颖,王宪波..Hedgehog信号通路在肝细胞癌中的作用及其与肿瘤微环境的关系[J].临床肝胆病杂志,2024,40(4):822-827,6.基金项目
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023005) （zyyzdxk-2023005）
首都卫生发展科研专项(2024-1-2173)State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project of Traditional Chinese Medicine(zyyzdxk-2023005) （2024-1-2173）
Capital Health Development Research Project(2024-1-2173) （2024-1-2173）
