临床肝胆病杂志2024，Vol.40Issue(4)：839-843,5.DOI:10.12449/JCH240432
巨噬细胞胞葬功能在急慢性肝病中的作用机制及其靶向治疗
Mechanism of action of macrophage efferocytosis in acute and chronic liver diseases and related targeted therapy
摘要
Abstract
Efferocytosis refers to the process by which apoptotic cells are engulfed and cleared by phagocytes,including professional phagocytes,such as macrophages and dendritic cells,and non-professional phagocytes,such as epithelial cells.Liver macrophages are the main cells with the function of efferocytosis in the liver.In recent years,an increasing number of studies have shown that various acute and chronic liver diseases are associated with the efferocytosis function of liver macrophages,including acute liver injury,alcoholic liver disease,nonalcoholic fatty liver disease,autoimmune liver disease,liver fibrosis,and liver cancer.This article elaborates on the expression of molecules associated with the efferocytosis function of macrophages,the process of efferocytosis,and the role of efferocytosis function in different liver diseases,so as to provide new ideas for the treatment of liver diseases.关键词
肝疾病/巨噬细胞/胞葬Key words
Liver Diseases/Macrophages/Efferocytosis引用本文复制引用
杨焕焕,袁诗雨,唐映梅..巨噬细胞胞葬功能在急慢性肝病中的作用机制及其靶向治疗[J].临床肝胆病杂志,2024,40(4):839-843,5.基金项目
国家自然科学基金(82360108) （82360108）
云南省医学领军人才项目(L-2019013) （L-2019013）
云南万人计划名医专项(YNWR-MY-2018-028) （YNWR-MY-2018-028）
云南省科技人才与平台计划(院士专家工作站202305AF150065) （院士专家工作站202305AF150065）
昆明医科大学第二附属医院临床研究项目(2020ynlc010,ynIIT2021017)National Natural Science Foundation of China(82360108) （2020ynlc010,ynIIT2021017）
Medicine Leading Talents of Yunnan Province(L-2019013) （L-2019013）
The Yunnan Wanren Project(YNWR-MY-2018-028) （YNWR-MY-2018-028）
Yunnan Province Science And Technology Talents and Platform Plan(The Yunan Academician Expert Workstation 202305AF150065) （The Yunan Academician Expert Workstation 202305AF150065）
Clinical Research Project of the Second Affiliated Hospital of Kunming Medical University(2020ynlc010,ynIIT2021017) （2020ynlc010,ynIIT2021017）
