临床误诊误治2024，Vol.37Issue(3)：114-118,5.DOI:10.3969/j.issn.1002-3429.2024.03.023
胸腺法新对紫杉醇、顺铂联合方案治疗中晚期食管癌增效减毒作用研究
Study on the Synergistic and Attenuating Effects of Thymalfasin on Paclita-xel Combined with Cisplatin Regimen in the Treatment of Advanced Esophageal Cancer
摘要
Abstract
Objective To explore the synergistic and attenuating effects of Thymalfasin on paclitaxel combined with cisplatin(TP)regimen in the treatment of advanced esophageal cancer.Methods A total of 120 patients with moderate and advanced esophageal cancer treated from June 2021 to June 2023 were randomly divided into observation group(n =60)and control group(n =60).The control group was treated with TP regimen,and the observation group was treated with Thymalfa-sin combined with TP regimen.The efficacy,improvement rate of quality of life,toxicity,1-year survival rate and the levels of T lymphocyte subsets,carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag)and carbohydrate anti-gen 19-9(CA19-9)before and after treatment were compared between the two groups.Results The objective remission rate,improvement rate of quality of life and 1-year survival rate in observation group were higher than those in control group,while the incidence of nausea,vomiting and myelosuppression was lower than that in control group(P<0.05).After 1 and 4 cour-ses of treatment,CD8 +,CD4 +,CD3 +,and CD4 +/CD8 + in the observation group had a higher improvement than that in the control group(P<0.05).Serum CEA,SCC-Ag and CA19-9 levels in the two groups after 1 and 4 courses of treatment were lower than those before treatment,and lower in the observation group than in the control group(P<0.05).Conclusion Thymalfasin can enhance the immune function of the body and play a synergistic and attenuating role in the treatment of ad-vanced esophageal cancer by TP regimen.关键词
食管肿瘤/增效减毒/紫杉醇/胸腺法新/顺铂/T淋巴细胞/癌胚抗原/鳞状细胞癌抗原Key words
Esophageal neoplasms/Synergistic and attenuating effect/Paclitaxel/Thymalfasin/Cisplatin/T-Lymphocytes/Carcinoembryonic antigen/Squamous cell carcinoma antigen分类
医药卫生引用本文复制引用
徐长龙,王仟慧..胸腺法新对紫杉醇、顺铂联合方案治疗中晚期食管癌增效减毒作用研究[J].临床误诊误治,2024,37(3):114-118,5.基金项目
2019年安徽省重点研究与开发计划项目(201904407020060) （201904407020060）
