临床误诊误治2024，Vol.37Issue(3)：136-142,7.DOI:10.3969/j.issn.1002-3429.2024.03.027
加味四物乌沉汤治疗肝郁血瘀证子宫内膜损伤致月经量少的临床效果及相关机制
Clinical Effect and Related Mechanism of Supplemented Siwu Wuchen De-coction in Treating Low Menstrual Volume Caused by Endometrial Injury in Patients with Liver-stagnation and Blood-stasis Syndrome
摘要
Abstract
Objective To investigate the clinical effect and related mechanism of supplemented Siwu Wuchen decoc-tion in treating low menstrual volume caused by endometrial injury in patients with liver-stagnation and blood-stasis syndrome.Methods A total of 180 patients with endometrial injury caused by liver-stagnation and blood-stasis syndrome treated from January 2020 to December 2022 were randomly divided into control group and observation group,with 90 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with supplemented Siwu Wuchen decoction on this basis for 6 consecutive menstrual cycles.The clinical efficacy,TCM syndrome score,endome-trial thickness,blood volume,duration of menstruation,endometrial arterial blood flow[pulsation index(PI),vascular re-sistance index(RI),peak systolic velocity(PSV)],sex hormone[estradiol(E2),luteinizing hormone(LH),prolactin(PRL),follicle stimulating hormone(FSH)],vascular endothelial growth factor(VEGF)/transforming growth factor-β1(TGF-β1)signaling pathway-related factors and adverse reactions were compared between the two groups.Results The total effective rate of observation group was91.11%(82/90),which was higher than that of control group[76.67%(69/90)](P<0.05).After 3 and6 cycles of treatment,the scores of TCM syndromes in the observation group were lower than those in the control group,the blood volume and endometrial thickness in the observation group were higher than those in the control group,and the duration of menstruation was longer than that in the control group(P<0.05).After 3 and 6 cycles of treat-ment,RI,PI,PRL and FSH in observation group were lower than those in control group,while PSV,E2,LH,VEGF and TGF-β1 were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Siwu Wuchen decoction has good clinical effects in treating low menstrual volume caused by endometrial injury in patients with liver-stagnation and blood-stasis syndrome,and can improve clinical symptoms and endometrial blood perfusion,the mechanism of which may be related to improving endome-trial thickness,regulating sex hormone levels and VEGF/TGF-β1 signaling pathway.关键词
子宫内膜损伤/月经量少/肝郁血瘀/加味四物乌沉汤/证候/雌二醇/血管内皮生长因子/转化生长因子-β1Key words
Endometrial injury/Low menstrual volume/liver-stagnation and blood-stasis/Supplemented Siwu Wuchen decoction/Syndrome/Estradiol/Vascular endothelial growth factor/Transforming growth factor-β1分类
医药卫生引用本文复制引用
梅莉,刘华骅,黄爱红,刘开颜..加味四物乌沉汤治疗肝郁血瘀证子宫内膜损伤致月经量少的临床效果及相关机制[J].临床误诊误治,2024,37(3):136-142,7.基金项目
2021年度南通市基础研究和民生科技计划指导性项目(MSZ21006) （MSZ21006）
