辽宁大学学报（自然科学版）2024，Vol.51Issue(1)：33-44,12.
基于CiteSpace及VOSviewer对乳腺癌中PI3K/Akt/mTOR信号通路的可视化分析
Visualization Analysis of PI3K/Akt/mTOR Signaling Pathway in Breast Cancer Based on CiteSpace and VOSviewer
沈继伟 1王智 1傅浩栋 1车晋 1高俊峰 1刘举 1陈烨2
作者信息
- 1. 辽宁大学 药学院,辽宁 沈阳 110036
- 2. 辽宁大学 药学院,辽宁 沈阳 110036||辽宁省小分子靶向药物研发工程研究中心,辽宁 沈阳 110036
- 折叠
摘要
Abstract
Objective:To analyze the research status and development trend of phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/Akt/mTOR)signaling pathway in breast cancer by bibliometric method,and to provide new ideas for the subsequent treatment of breast cancer.Methods:Literature related to PI3K/Akt/mTOR signaling pathway in breast cancer from January 1,2003 to June 30 2022 was retrieved through Web of Science,and bibliometrics was used for data mining.CiteSpace 6.1R2 and VOSviewer software were used for data analysis and visual analysis.Results:A total of 1209 articles were retrieved.In recent years,the number of articles related to PI3K/Akt/mTOR signaling pathway in breast cancer fluctuated.American authors represented by Kurzrock Razelle were the most prolific.The high-frequency keywords included breast cancer,expression and PI3K/Akt/mTOR signaling pathway,etc.A total of 15 clusters including endocrine resistance have been formed,among which tumor microenvironment,cell cycle arrest and mTOR signaling pathway have been the research trends in the past two years.Conclusions:PI3K/Akt/mTOR signaling pathway played an important role in the treatment of breast cancer,and research targeting PI3K/Akt/mTOR signaling pathway inhibitors was the focus of research for the treatment of breast cancer.关键词
乳腺癌/PI3K/Akt/mTOR/CiteSpace/VOSviewer/可视化分析Key words
breast cancer/PI3K/Akt/mTOR/CiteSpace/VOSviewer/visual analysis分类
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沈继伟,王智,傅浩栋,车晋,高俊峰,刘举,陈烨..基于CiteSpace及VOSviewer对乳腺癌中PI3K/Akt/mTOR信号通路的可视化分析[J].辽宁大学学报（自然科学版）,2024,51(1):33-44,12.
