辽宁大学学报（自然科学版）2024，Vol.51Issue(1)：45-51,7.
N1,N12-二乙酰精胺在肠癌中的含量水平及其临床早期诊断意义
The Level of N1,N12-Diacetylspermine in Colorectal Cancer and Early Clinical Diagnostic Significance
摘要
Abstract
Objective To explore the content of N1,N12-diacetylspermine(DiAcSpm)in colorectal cancer and its clinical early diagnostic significance.Method Content of DiAcSpm in 60 cases of colorectal cancer and 22 cases of corresponding para-carcinoma colorectal mucosa tissues were detected by immunohistochemical method.Result The positive rate of DiAcSpm in colorectal cancer was 75.0%,compared to para-carcinoma colorectal tissues 22.7%.The content of DiAcSpm was correlated with proliferative marker protein(Ki-67),but not correlated with patients'age,gender,tumor differentiation and tumor node metastasis(TNM)stage.Conclusion High level of DiAcSpm in colorectal cancer was involved in malignant proliferation,and DiAcSpm could be a novel molecular marker for early diagnosis.关键词
N1,N12-二乙酰精胺/肠癌/早期诊断Key words
N1,N12-diacetylspermine/colorectal cancer/early diagnosis分类
医药卫生引用本文复制引用
牟藤,初廷广,李文欣,董千泽,刘勇..N1,N12-二乙酰精胺在肠癌中的含量水平及其临床早期诊断意义[J].辽宁大学学报（自然科学版）,2024,51(1):45-51,7.基金项目
辽宁省重点研发计划指导计划项目(2017226010) （2017226010）
