中国临床保健杂志2024，Vol.27Issue(1)：60-64,5.DOI:10.3969/J.issn.1672-6790.2024.01.013
城市社区老年人胰岛素抵抗与认知障碍的相关性研究
A study on the correlation between insulin resistance and cognitive impairment in elderly people in urban communities
摘要
Abstract
Objective To explore the relationship between insulin resistance and cognitive dysfunction in the elderly in urban communities,and to provide new ideas for the early identification and prevention of cognitive dysfunction in the elderly.Methods From January 2019 to July 2022,a total of 495 elderly people aged 60 and above were includ-ed in a community in Hefei City.Basic data(including gender,age,educational level,height,weight,body mass index,waist-to-hip ratio,etc.),medical history,and biochemical indicators(including blood lipid,fasting blood glucose,fasting insulin,glycated hemoglobin,25 hydroxyvitamin D,etc.)were recorded.Cognitive function level was assessed by the Montreal Cognitive Assessment(MoCA).Subjects were divided into a cognitive impairment group(MC group)and a non-MC group(non-MC group)according to MoCA score.Factors affecting the occurrence of cognitive impairment were analyzed,and insulin resistance(IR)level was assessed according to the homeostasis model Insulin resistance index(HOMA-IR),and divided into 4 groups by HOMA-IR quartile method,Q1:HOMA-IR≤1.325 2,Q2:1.325 2＜HO-MA-IR≤1.995 8,Q3:1.995 8＜HOMA-IR ≤2.646 5,Q4:HOMA-IR＞2.646 5,the prevalence of cognitive impair-ment in the four groups was compared,and the relationship between insulin resistance and cognitive impairment was ana-lyzed by binary logistic regression.Results Compared with the n-MC group,the MC group was older and less educated(P＜0.05),but there was no significant difference in hypertension history,diabetes history,marital status,and working status between the two groups(P＞0.05).The levels of HbA1c,total cholesterol,and HOMA-IR in the MC group were higher,while the levels of vitamin D were lower,and the difference was statistically significant(P＜0.05).The increase in HOMA-IR value was positively correlated with the occurrence of cognitive dysfunction(P＜0.01).Conclusion In-sulin resistance is a risk factor for cognitive impairment in elderly people in urban communities.关键词
认知障碍/胰岛素抵抗/危险因素/老年人Key words
Cognition disorders/Insulin resistance/Risk factors/Aged引用本文复制引用
解馨瑜,何阳,沈伟,张薇薇,葛余浩,康冬梅..城市社区老年人胰岛素抵抗与认知障碍的相关性研究[J].中国临床保健杂志,2024,27(1):60-64,5.基金项目
国家自然科学基金项目(82271617) （82271617）
中国科学院战略性先导科技专项(B类)(XDB39040500) （B类）
安徽省科技厅重点研发项目(202004j07020012) （202004j07020012）
