中南医学科学杂志2024，Vol.52Issue(2)：157-162,6.DOI:10.15972/j.cnki.43-1509/r.2024.02.001
SFXN家族蛋白的功能及其在疾病中作用的研究进展
Research progress on the functions of SFXN family proteins and their roles in diseases
摘要
Abstract
SFXN is a highly conserved multi-transmembrane mitochondrial protein in eukaryotes,belonging to the mitochondrial vector family.In human cells,the SFXN family comprises five proteins,i.e.,SFXN1～5,whose functions are closely related to iron homeostasis,amino acid metabolism,and tricarboxylic acid cycle.The expression abnormalities caused by SFXN gene mutations are closely related to the occurrence and development of cancer and neurodegenerative diseases.This review mainly summarizes the localization,mitochondrial transport,and physiological functions of SFXN family proteins,and introduces the latest research progress about its roles in cancer,neurodegenerative diseases,and mitochondrial diseases.关键词
SFXN/铁代谢/单碳代谢/三羟酸循环/癌症/神经退行性疾病/线粒体疾病Key words
SFXN/iron metabolism/one carbon metabolism/tricarboxylic acid cycle/cancer/neurodegenerative disease/mitochondria disease分类
生物科学引用本文复制引用
何也川,王丹玲..SFXN家族蛋白的功能及其在疾病中作用的研究进展[J].中南医学科学杂志,2024,52(2):157-162,6.基金项目
国家自然科学基金面上项目(30971469) （30971469）
国家自然科学青年科学基金项目(30800586) （30800586）
湖南省科技创新重点工程项目(2021SK1014) （2021SK1014）
