低剂量槟榔碱增强小鼠生理性记忆并改善记忆障碍OACSTPCD

Aim To explore the effects of arecoline on physiological memory and MK-801-induced memory impairment in mice.Methods 24 mice were randomly divided into control group,low-dose arecoline group and high-dose arecoline group.The effects of arecoline on physiological memory were analyzed by using discrimination index(DI)according to novel object recognition(NOR)task and object location recognition(OLR)task.In addition,32 mice were randomly divided into normal group,MK-801 group,MK-801 combined with low-dose arecoline drinking group(L-ARE treatment group),and MK-801 combined with high-dose arecoline drinking group(H-ARE treatment group).The effects of arecoline on MK-801-induced memory impairment in mice were analyzed by using DI of NOR,OLR.Results Compared with the control group,the DI of NOR,OLR in low-dose arecoline group was significantly increased(P<0.05).However,there was no significant difference between high dose arecoline group and control group(P>0.05).Compared with normal group,the DI of NOR,OLR in MK-801 group were decreased(P<0.05).Compared with MK-801 group,the DI of mice in L-ARE treatment group was significantly increased(P<0.05).Meanwhile,the DI in H-ARE treatment group was also increased,but there was no statistical difference(P>0.05).Conclusion Low doses of arecoline can enhance memory performance in mice under physiological conditions and improve memory impairment.