中南医学科学杂志2024，Vol.52Issue(2)：206-209,4.DOI:10.15972/j.cnki.43-1509/r.2024.02.011
ADAMTS-7基因rs3825807及rs1994016位点多态性与KD发病及CAL的关联性分析
The association between polymorphism of ADAMTS-7 gene and the pathogenesis of KD and coronary artery injury
摘要
Abstract
Aim To investigate the association of polymorphisms at loci rs3825807 and rs1994016 of ADAMTS-7 gene with the pathogenesis of Kawasaki disease(KD)and coronary artery lesion(CAL).Methods 100 children with KD were selected as the KD group,and 100 healthy children undergoing physical examinations were selected as the healthy group.Two sets of peripheral blood DNA were extracted for gene sequencing to compare the polymorphism differences at rs3825807 and rs1994016 loci of the AD-AMTS-7 gene between the two groups.The KD group was divided into a coronary artery injury group(KD-CAL group)and a non-coronary artery injury group(KD-NCAL group)based on the presence of coronary artery injury.The polymorphism differences at ADAMTS-7 rs3825807 and rs1994016 loci were compared between the two groups.Results The frequency of polymorphic A and G alleles,the genotype frequencies of AA,AG,and GG at the rs3825807 locus of ADAMTS-7 gene,as well as the frequency of poly-morphic C and T alleles,the genotype frequencies of CC,CT,and TT at the rs1994016 locus,were not statistically significant different between the KD group and the healthy group,or between the KD-NCAL group and the KD-CAL group(P>0.05).Conclusion There is no significant association between polymorphisms at the rs3825807 and rs1994016 loci of ADAMTS-7 gene and the incidence of KD and CAL.关键词
川崎病/冠状动脉损伤/ADAMTS-7基因/基因多态性/rs3825807位点/rs1994016位点Key words
KD/CAL/ADAMTS-7 gene/gene polymorphism/loci rs3825807/loci rs1994016分类
医药卫生引用本文复制引用
张亚南,李卓颖,杨作成,黄利华,芮兆梅..ADAMTS-7基因rs3825807及rs1994016位点多态性与KD发病及CAL的关联性分析[J].中南医学科学杂志,2024,52(2):206-209,4.基金项目
国家自然科学基金(81800440) （81800440）
