青岛大学学报（医学版）2024，Vol.60Issue(1)：72-76,5.DOI:10.11712/jms.2096-5532.2024.60.034
Ⅲ期结直肠癌血清细胞因子水平与术后短期复发关系
Association between serum cytokine levels and postoperative short-term recurrence in patients with stage Ⅲ colorectal cancer
摘要
Abstract
Objective To investigate the association between serum cytokine levels before chemotherapy and recurrence within 1 year after surgery in patients with stage Ⅲ colorectal cancer.Methods A retrospective analysis was performed for 90 patients with stage Ⅲ colorectal cancer who underwent surgery,among whom 31 patients with recurrence,metastasis,or death within 1 year after surgery were included as recurrence group,and the remaining 59 patients were included as non-recurrence group.The two groups were compared in terms of the serum levels of cytokines[interferon-α(IFN-α),interferon-γ(IFNγ),tumor nec-rosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-2,interleukin-4,interleukin-5(IL-5),interleukin-6(IL-6),interleu-kin-8(IL-8),interleukin-10,interleukin-12P,and interleukin-17]and tumor markers(carcinoembryonic antigen,carbohydrate antigen 199,carbohydrate antigen 72-4,carbohydrate antigen 242,and alpha-fetoprotein)before initial treatment.A Logistic re-gression analysis was used to investigate the independent risk factors for recurrence within 1 year,and the receiver operating cha-racteristic(ROC)curve was used to analyze the value of cytokines in the diagnosis of recurrence within 1 year after surgery.Re-sults The recurrence group had significantly higher levels of IL-1β,IL-5,IL-6,and IL-8 than the non-recurrence group(Z=-3.316 to-2.113,P＜0.05).The ROC curve analysis showed that IL-6 had a significantly higher diagnostic value than the other cytokines,with an area under the ROC curve(AUC)of 0.714(95％CI=0.601-0.826,P＜0.05).Among the 47 patients with normal tumor markers,the recurrence group had significantly higher levels of IL-6 and TNF-α than the non-recurrence group(Z=-2.365,-2.170,P＜0.05),and the ROC curve analysis showed that IL-6 and TNF-a had a significantly higher diagnostic value than the other cytokines(IL-6:AUC=0.768,95％CI=0.608-0.921,P＜0.05;TNF-α:AUC=0.745,95％CI=0.583-0.953,P＜0.05).The multivariate analysis showed that elevated serum IL-1p level was an independent risk factor for recurrence and metastasis within 1 year in patients with stage Ⅲ colorectal cancer(β=-1.506,P＜0.05).Conclusion The serum levels of IL-6,IL-1β,IL-8,and TNF-α before postoperative adjuvant therapy for stage m colorectal cancer can be used as auxiliary indices to predict tumor recurrence within 1 year after surgery.关键词
结直肠肿瘤/放化疗,辅助/细胞因子类/预后Key words
colorectal neoplasms/chemoradiotherapy,adjuvant/cytokines/prognosis分类
医药卫生引用本文复制引用
边晓倩,王莎莎,赵淑芬,王赫,孙丽斌,齐卫卫..Ⅲ期结直肠癌血清细胞因子水平与术后短期复发关系[J].青岛大学学报（医学版）,2024,60(1):72-76,5.基金项目
山东省医药卫生科技发展计划项目(20200-3030451) （20200-3030451）
北京科创医学发展基金会(KC2021-JX-0186-145) （KC2021-JX-0186-145）
