中南医学科学杂志2024，Vol.52Issue(2)：295-299,5.DOI:10.15972/j.cnki.43-1509/r.2024.02.036
蛋白质硝基化修饰在心力衰竭发生发展中的作用
The role of protein nitration modification in the development and progression of heart failure
摘要
Abstract
Nitrative stress is a biochemical reaction that occurs in combination with reactive oxygen species(ROS)and nitric oxide or with active nitrogen species(RNS)derived from nitric oxide.Under stress,the body produces a high concentration of super-oxide anion(O2-)and nitric oxide,and the reaction of the two can produce peroxynitrite,which makes the protein tyrosine residue un-dergo nitration modification to produce 3-nitrotyrosine(3-NT).Therefore,3-NT is usually used to reflect the level of protein nitration modification.The accumulated 3-NT leads to DNA damage,cell death,cardiac structure damage,and cardiac dysfunction.Heart failure,a clinical syndrome that arises in the terminal stages of cardiovascular disease,is one of the important public health problems worldwide.The causes of heart failure are diverse,and it is characterized by high morbidity and poor prognosis.During the patho-logical process of heart failure,nitrative stress levels are markedly elevated in the heart,with a large number of proteins undergoing ni-tration modification and a concomitant increase in 3-NT production.This review focuses on the role of protein nitration modification in the development and progression of heart failure.关键词
蛋白质/硝基化/心力衰竭/3-硝基酪氨酸/硝基化应激Key words
protein/nitration/heart failure/3-nitrotyrosine/nitrative stress分类
医药卫生引用本文复制引用
马湘宜,柴嘉音,孟艳,王雯..蛋白质硝基化修饰在心力衰竭发生发展中的作用[J].中南医学科学杂志,2024,52(2):295-299,5.基金项目
国家自然科学基金(91839107) （91839107）
北京市自然科学基金(7242005) （7242005）
首都医科大学2022年本科生科研创新项目(XSKY2022031) （XSKY2022031）
