青岛大学学报（医学版）2024，Vol.60Issue(1)：110-114,5.DOI:10.11712/jms.2096-5532.2024.60.006
不可逆电穿孔和射频消融治疗原发性肝癌效果比较
Efficacy of irreversible electroporation versus radiofrequency ablation for primary liver cancer
摘要
Abstract
Objective To preliminarily evaluatethe therapeutic effects of irreversible electroporation for primary liver cancer.Methods From January 2019 to October 2021,we prospectivelyenrolled 102 patients with primary liver cancer who were trea-ted at Hebei PetroChina Central Hospital,and assigned them using a random number tableto receive either irreversible electropora-tion(observation group)or radiofrequency ablation(control group),with 51 patients in each group.The two groups were com-pared in terms of clinical response,postoperative complications,survival and recurrence rates at 6 and 12 months,and the clea-rancerate of alpha fetoprotein(AFP),as well as biochemical indicators including total bilirubin(TBil),albumin(Alb),alanine ami-notransferase(ALT),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),and AFP levels.Results Com-pared with the control group,the observation group showed significantly higher overall clinical response rate,6-and 12-month sur-vival rates,and AFP clearance rate(x2=7.933,8.254;Log-rank x2=8.254,8.541;all P＜0.05)and significantly lower incidence rate of postoperative complications and recurrence rates at 6 and 12 months(x2=4.317;Log-rank x2=6.331,7.256;all P＜0.05).ALT,Alb,TBil,AFP,CEA,and CA125 levels in the observation group were significantly lower than those in the control group(t=8.660-40.741,all P＜0.05).Conclusion Irreversible electroporation has significant therapeutic effectsforpatients with pri-mary liver cancer,and can effectively reduce serum ALT,Alb,and TBil levels,with less detrimental impact on liver function.关键词
肝肿瘤/电穿孔/射频消融术/肝功能试验/生物标记,肿瘤/治疗结果Key words
liver neoplasms/electroporation/radiofrequency ablation/liver function tests/biomarkers,tumor/treatment outcome分类
医药卫生引用本文复制引用
赵孟杰,邢恩涛,董源,金鹏飞,孙景武..不可逆电穿孔和射频消融治疗原发性肝癌效果比较[J].青岛大学学报（医学版）,2024,60(1):110-114,5.基金项目
河北省重点研发计划自筹项目(172777148) （172777148）
