青岛大学学报（医学版）2024，Vol.60Issue(1)：124-128,5.DOI:10.11712/jms.2096-5532.2024.60.013
脾硬度及血小板计数联合脾脏大小在肝硬化食管胃底静脉曲张诊断中的应用
Application of spleen stiffness and platelet count plus spleen size in the diagnosis of gastroesophageal varices in liver cirrhosis
摘要
Abstract
Objective To investigate the value of spleen stiffness measurement(SSM)and platelet count(PLT)combined with spleen size for the diagnosis of gastroesophageal varices(GOV)in patients with liver cirrhosis.Methods We included 109 patients with hepatitis B cirrhosis admitted to our hospital.They underwent ultrasonography for spleen thickness(ST)and spleen diameter(SD)and transient elastography for SSM as well as serological examination and gastroscopy.A Logistic regression analy-sis was performed to analyze the relationship between moderate-to-severe GOV and SSM,PLT/SD,and PLT/ST in patients with hepatitis B cirrhosis.Results There were significant differences in SSM,PLT/ST,and PLT/SD between the patients with GOV and those without GOV(Z=3.03-5.53,P＜0.05).The regression model for determining moderate-to-severe GOV was as following:Logit(P)=-6.373+0.298 X SSM-0.443 X PLT/ST.The areas under the receiver operating characteristic curves of SSM,PLT/ST,PLT/SD,and the regression model for diagnosing moderate-to-severe GOV were 0.94,0.79,0.77,and 0.95,re-spectively.Conclusion SSM,PLT/ST,and PLT/SD have certain value for determining the presence or absence of GOV in liver cirrhosis,and SSM is superior to PLT/ST and PLT/SD in predicting moderate-to-severe GOV.The model combining SSM,PLT,spleen size can be an invasive alternative for the diagnosis of moderate-to-severe GOV.关键词
肝硬化/食管和胃静脉曲张/脾/超声检查/弹性成像技术/血小板计数/诊断Key words
liver cirrhosis/esophageal and gastric varices/spleen/ultrasonography/elasticity imaging techniques/platelet count/diagnosis分类
医药卫生引用本文复制引用
王硕,王建红,张迪,吴晓冬,杨子祯,蔡金贞..脾硬度及血小板计数联合脾脏大小在肝硬化食管胃底静脉曲张诊断中的应用[J].青岛大学学报（医学版）,2024,60(1):124-128,5.基金项目
青岛大学附属医院青年科研基金(QYFY-2021-36) （QYFY-2021-36）
