上海针灸杂志2024，Vol.43Issue(4)：422-427,6.DOI:10.13460/j.issn.1005-0957.2024.04.0422
针刺联合桑寄生汤治疗类风湿关节炎的疗效观察及对促炎细胞因子水平的影响
Observation of the therapeutic effect of acupuncture combined with Sang Ji Sheng Tang in the treatment of rheumatoid arthritis and its effect on the levels of pro-inflammatory factors
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture combined with Sang Ji Sheng Tang in the treatment of rheumatoid arthritis(RA)and its effect on serum levels of angiogenesis related cytokines and pro-inflammatory cytokines.Method A total of 100 patients with RA were randomly divided into a control group and a combination group,with 50 cases in each group.The control group was treated with Sang Ji Sheng Tang,and the combination group was treated with acupuncture combined with Sang Ji Sheng Tang.Before and after treatment,the changes of morning stiffness time,20 m walking time,pain numerical rating scale(NRS)score,TCM syndrome score,disease activity score 28(DAS28)of RA patients,and the health assessment questionnaire-disability index(HAQ-DI)score were observed in the two groups.The serum glycosyl phosphatidyl inositol(GPI),basic fibroblast growth factor(bFGF),C reactive protein(CRP),macrophage colony stimulating factor(M-CSF),interleukin-32(IL-32),vascular endothelial growth factor(VEGF),superoxide dismutase(SOD),reactive oxygen species(ROS),transforming growth factor-β1(TGF-β1),bradykinin(BK)and β-endorphin(β-EP)levels were observed in the two groups before and after treatment.The clinical efficacy was compared between the two groups.Result After treatment,the morning stiffness time and 20 m walking time were shortened in the two groups(P＜0.05),and those in the combination group were shorter than those in the control group(P＜0.05).The NRS score,TCM syndrome score,RA DAS28 score and HAQ-DI score of the two groups were decreased(P＜0.05),and those of the combination group were lower than those of the control group(P＜0.05).The serum levels of CRP,GPI,M-CSF,IL-32,ROS,BK,bFGF,VEGF and TGF-β1 in the two groups were decreased(P＜0.05),and those in the combination group were lower than those in the control group(P＜0.05).The serum SOD and β-EP levels were increased in the two groups(P＜0.05),and those in the combination group were higher than those in the control group(P＜0.05).The total effective rate of the combination group was 98.0%,which was higher than 82.0%of the control group(P＜0.05).Conclusion Acupuncture combined with Sang Ji Sheng Tang in the treatment of RA can relieve the clinical symptoms,improve the clinical response,and improve the quality of life of patients,and the therapeutic effect is better than taking Sang Ji Sheng Tang alone.In addition,it can reduce the level of pro-inflammatory factors,inhibit inflammation,improve antioxidant capacity,and reduce angiogenesis related cytokines.关键词
针刺疗法/针药并用/关节炎,类风湿/抗氧化/促炎因子Key words
Acupuncture therapy/Acupuncture medication combined/Arthritis,rheumatoid/Antioxidant/Pro-inflammatory factors分类
医药卫生引用本文复制引用
李波,涂元宝,金秀娟,唐燕..针刺联合桑寄生汤治疗类风湿关节炎的疗效观察及对促炎细胞因子水平的影响[J].上海针灸杂志,2024,43(4):422-427,6.基金项目
国家卫生发展科研专项项目(21-0-1-15-YHC) （21-0-1-15-YHC）
