上海针灸杂志2024，Vol.43Issue(4)：428-433,6.DOI:10.13460/j.issn.1005-0957.2024.04.0428
电针辅助治疗类风湿关节炎的疗效观察及对血清类风湿因子和炎症因子的影响
Effecacy observation of electroacupuncture in the adjuvant treatment of rheumatoid arthritis and its influence on serum rheumatoid factor and inflammatory factors
摘要
Abstract
Objective To observe the clinical efficacy of electroacupuncture at Zusanli(ST36)and Guanyuan(CV4)in the adjuvant treatment of rheumatoid arthritis(RA)and its effect on joint function,joint tenderness index,erythrocyte sedimentation rate(ESR),rheumatoid factor(RF)and inflammatory factor.Method A total of 112 patients with RA were randomly divided into a control group and an observation group,with 56 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with electroacupuncture at Zusanli and Guanyuan on the basis of the treatment of the control group.The clinical efficacy and adverse reactions of the two groups were compared.The joint function,joint swelling index,joint tenderness index and disease activity score 28(DAS28)score,as well as ESR,RF and inflammatory factors[C-reactive protein(CRP),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)]levels were observed before and after treatment in the two groups.Result The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the scores of joint function(joint stiffness,pain and daily activities),DAS28 score,joint swelling index,joint tenderness index,and the levels of ESR,RF,CRP,TNF-α and IL-1β in the two groups were lower than those before treatment(P＜0.05),and those in the observation group were lower than those in the control group(P＜0.05).In the control group,1 patient had pharyngeal obstruction which was suspected to be caused by methotrexate,and 2 patients had gastrointestinal symptoms.In the observation group,2 cases had subcutaneous hematoma after acupuncture,and 1 case had gastrointestinal discomfort.Conclusion On the basis of conventional Western medicine treatment,electroacupuncture at Zusanli and Guanyuan can improve the clinical efficacy of RA,help to improve joint function and joint tenderness,and reduce ESR,RF and inflammatory factor levels.关键词
针刺疗法/电针/关节炎,类风湿/关节功能/关节压痛/类风湿因子/炎症因子Key words
Acupuncture therapy/Electroacupuncture/Arthritis,Rheumatoid/Joint function/Joint tenderness/Rheumatoid factor/Inflammatory factors分类
中医学引用本文复制引用
王晓云,高宇,文培培,刘益兵..电针辅助治疗类风湿关节炎的疗效观察及对血清类风湿因子和炎症因子的影响[J].上海针灸杂志,2024,43(4):428-433,6.基金项目
国家自然科学基金项目(81601368) （81601368）
河南省医学科技攻关计划(联合共建)项目(LHGJ20191139) （联合共建）
