上海针灸杂志2024，Vol.43Issue(4)：434-438,5.DOI:10.13460/j.issn.1005-0957.2024.04.0434
梅花针联合中药治疗银屑病的疗效观察及对Th1/Th2细胞因子和皮肤屏障功能的影响
Observation of the therapeutic effect of the plum-blossom needle combined with Chinese medication in treating psoriasis and its effect on Th1/Th2 cytokines and skin barrier function
摘要
Abstract
Objective To observe the clinical effect of the plum-blossom needle combined with modified Liang Xue Xiao Bi Tang in patients with psoriasis and its effect on serum Th1/Th2 cytokines levels and skin barrier function.Method Seventy-two patients with psoriasis were divided into a combination group(36 cases)and a control group(36 cases)according to the treatment methods.The control group was treated with conventional Western medicine.The combination group was treated with the plum-blossom needle combined with modified Liang Xue Xiao Bi Tang.The psoriasis area and severity index(PASI)score and serum Th1/Th2 cytokines[tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-10(IL-10),and interleukin-4(IL-4)]levels and the skin barrier function indexes(stratum corneum water content,sebum content and transepidermal water loss)were compared between the two groups before and after treatment.The clinical efficacy and adverse reactions were compared between the two groups.Result group was lower than that of the control group(P＜0.05).The serum levels of TNF-α and IFN-γ in the two groups were decreased(P＜0.05),and the serum levels of TNF-α and IFN-γ in the combination group were lower than those in the control group(P＜0.05).The serum levels of IL-10 and IL-4 in the two groups were increased(P＜0.05),and the serum levels of IL-10 and IL-4 in the combination group were higher than those in the control group(P＜0.05).The water content and sebum content of stratum corneum were increased in the two groups(P＜0.05),and those in the combination group were higher than the control group(P＜0.05).The transepidermal water loss in the combination group was lower than that in the control group(P＜0.05).The total effective rate of the combination group was higher than that of the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The plum-blossom needle combined with modified Liang Xue Xiao Bi Tang can improve the clinical symptoms of patients with psoriasis,regulating Th1/Th2 cytokines level in serum,repair the skin barrier function,and improve clinical therapeutic effect.关键词
梅花针疗法/皮肤针疗法/针药并用/银屑病/皮损/皮肤屏障Key words
Plum-blossom needle therapy/Dermal needle therapy/Acupuncture medication combined/Psoriasis/Skin lesions/Skin barrier分类
医药卫生引用本文复制引用
杜笑青,石丽平,姚丽敏,吴琼,马旭..梅花针联合中药治疗银屑病的疗效观察及对Th1/Th2细胞因子和皮肤屏障功能的影响[J].上海针灸杂志,2024,43(4):434-438,5.基金项目
河北省医学科学研究课题计划项目(20211587,20231294) （20211587,20231294）
