上海针灸杂志2024，Vol.43Issue(4)：445-450,6.DOI:10.13460/j.issn.1005-0957.2024.04.0445
温针灸治疗儿童癫痫的疗效观察及对血清PSD-95水平的影响
Observation of the therapeutic effect of needle-warming moxibustion in the treatment of children with epilepsy and its effect on serum PSD-95 level
摘要
Abstract
Objective To observe the clinical efficacy of needle-warming moxibustion at Yongquan(KI1)and Baihui(GV20)in the treatment of epilepsy in children and its effect on the nerve injury state and serum postsynaptic density 95(PSD-95)level.Method A total of 110 children with epilepsy were divided into a control group and an observation group according to different treatment methods,with 55 cases in each group.The control group was treated with oral Lamotrigine,and the observation group was treated with needle-warming moxibustion at Yongquan and Baihui on the basis of oral medication in the control group.The clinical efficacy was compared between the two groups,and the scores of Wechsler intelligence scale for children Ⅳ(WISC-Ⅳ)and mini-mental state examination(MMSE)were observed before and after treatment in the two groups.The changes of MMSE score,seizure frequency,seizure duration,electroencephalogram(EEG)indexes,S100β level,glial fibrillary acidic protein(GFAP)level and PSD-95 level were observed.Result The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the scores of WISC-Ⅳ and MMSE in the observation group were higher than those in the control group(P＜0.05),the frequency of seizures was lower than that in the control group(P＜0.05),and the duration of seizures was shorter than that in the control group(P＜0.05).After treatment,the β power,δ power,θ power and α power of EEG in the observation group were higher than those in the control group(P＜0.05).After treatment,the serum levels of S100β and GFAP in the observation group were lower than those in the control group(P＜0.05),and the serum level of PSD-95 was higher than that in the control group(P＜0.05).Conclusion On the basis of oral Lamotrigine,needle-warming moxibustion at Yongquan and Baihui in the treatment of children with epilepsy can improve the state of nerve injury,improve cognitive function and mental state,reduce the frequency of seizures,shorten the duration of seizures,up-regulate the expression of serum PSD-95,reduce the levels of serum S100β and GFAP,and improve the clinical efficacy.关键词
温针疗法/针药并用/穴,涌泉/穴,百会/癫痫/儿童/神经功能/突触后致密区95Key words
Needle warming therapy/Acupuncture medication combined/Acupoint,Yongquan(KI1)/Acupoint,Baihui(GV20)/Epilepsy/Children/Neurological function/Postsynaptic density 95分类
医药卫生引用本文复制引用
秦玲玲,孟祥磊,梁力泳,杨添淞..温针灸治疗儿童癫痫的疗效观察及对血清PSD-95水平的影响[J].上海针灸杂志,2024,43(4):445-450,6.基金项目
国家自然科学基金项目(82074539) （82074539）
齐齐哈尔市科学技术计划项目(SFZD-2019117) （SFZD-2019117）
