有色金属材料与工程2024，Vol.45Issue(2)：55-61,7.DOI:10.13258/j.cnki.nmme.20230320001
抗生素亚胺培南探针分子设计及传感性能研究
Design and sensing property of probe molecular for imipenem antibiotic
摘要
Abstract
Medication management of antibiotic imipenem(IPM)in the treatment of sepsis infection requires rapid response,however,the current monitoring methods of blood drugs severely delay drug injection.The aim of this work is to design metal element doped graphene quantum dots(GQDs),which can rapidly detect IPM by fluorescence method,opening up a new way for fluorescence detection of antibiotics.Iron doped GQDs(Fe-GQDs)were prepared by hydrothermal method for rapid detection of IPM.The effects of different precursors of iron sources on the fluorescence and sensing performance of GQDs were investigated using transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),fluorescence spectroscopy,etc.The microstructure and fluorescence properties of Fe-GQDs prepared with iron acetate were analyzed.The results showed that Fe-GQDs prepared with iron acetate as the precursor exhibited the best fluorescence performance and a significant fluorescence quenching effect on IPM.The fluorescence quenching intensity(F/F0)of the as-prepared Fe-GQDs was linearly related to the concentration(C)of IPM,where the linear equation wasF/F0=0.983-4.23×10-3C with a linear correlation coefficient(R2)of 0.997 and a linear range of 0.007-0.073 g/L.The Fe-GQDs probe molecules delivered a good anti-interference performance against common organic molecules and metal ions in plasma with a detection error of 1.6%-4.6%for sensing IPM.关键词
石墨烯量子点/掺杂/抗生素/荧光性能/传感特性Key words
graphene quantum dots/doping/antibiotics/fluorescence performance/sensing property分类
化学引用本文复制引用
朱彦西,陈爱英,毛燕飞..抗生素亚胺培南探针分子设计及传感性能研究[J].有色金属材料与工程,2024,45(2):55-61,7.基金项目
国家自然科学基金资助项目(5177121) （5177121）
