山东科学2024，Vol.37Issue(2)：12-19,8.DOI:10.3976/j.issn.1002-4026.20240028
天然多酚类成分缓解高尿酸血症及其机制研究进展
Research progress on the mechanisms by which natural phenolic compounds alleviate hyperuricemia
摘要
Abstract
Hyperuricemia(HUA)is a metabolic disorder caused by the physiologic disorders in purine metabolism,resulting in increased serum uric acid levels,which can lead to gout in severe cases.HUA pathogenesis primarily involves enzyme dysfunction,urate transporter expression dysregulation,glucose and lipid metabolism disorders,and intestinal homeostasis disruption.Numerous studies have reported the effectiveness of natural polyphenols in alleviating hyperuricemia and gout.This article summarizes HUA pathogenesis and the mechanisms of action of polyphenolic compounds in reducing uric acid,to provide a theoretical basis for the research and development of uric acid-lowering drugs.关键词
多酚类成分/高尿酸血症/作用机制/研究进展Key words
polyphenols/hyperuricemia/mechanism of action/research progress分类
医药卫生引用本文复制引用
刘双,董红敬,陈盼盼,王晓..天然多酚类成分缓解高尿酸血症及其机制研究进展[J].山东科学,2024,37(2):12-19,8.基金项目
山东省重点研发计划(2021CXGC010508) （2021CXGC010508）
