山东科学2024，Vol.37Issue(2)：20-28,9.DOI:10.3976/j.issn.1002-4026.20240017
黄芩及其有效成分治疗溃疡性结肠炎机制研究进展
Progress in the research on the mechanism of action of Scutellaria baicalensis and its active ingredients in treating ulcerative colitis
摘要
Abstract
Ulcerative colitis(UC)is an inflammatory bowel disease characterized by persistent mucosal inflammation.Scutellaria baicalensis(also known as Huangqin),as a common traditional Chinese medicines used in clinical practice,is known for its efficacy at clearing internal heat,eliminating dampness,purging fire,eliminating toxins,stopping bleeding,and calming fetal activity.Its formulations,including Huangqin Decoction,Peony Decoction,and Pueraria,Scutellaria,and Coptis Decoction,are often used to treat damp-heat UC.Studies have shown that S.baicalensis and its active ingredients play an important role in protecting the intestinal mucosa,and have anti-inflammatory and immunomodulatory effects.This study reviews the mechanism of action of S.baicalensisand its active ingredients(baicalin,baicalein,oroxindin,wogonin,Scutellaria baicalensis polysaccharide,etc.)in the treatment of UC in recent years,including the protection and repair of the intestinal mucosal barrier,the active ingredients anti-inflammatory and immunomodulatory properties,effects against antioxidative stress,and regulation of intestinal flora,to provide a reference for targeted clinical treatment of UC and drug development.关键词
溃疡性结肠炎/黄芩/有效成分/作用机制Key words
ulcerative colitis/Scutellaria baicalensis/active ingredient/mechanism of action分类
医药卫生引用本文复制引用
罗雅琴,黄伟..黄芩及其有效成分治疗溃疡性结肠炎机制研究进展[J].山东科学,2024,37(2):20-28,9.基金项目
中央本级重大增减支项目(2060302) （2060302）
国家自然科学基金项目(81704029) （81704029）
山东省自然科学基金联合基金重点项目(ZR2022LZY007) （ZR2022LZY007）
山东省中医药高层次人才培育项目(鲁卫人才字[2023]37号) （鲁卫人才字[2023]37号）
齐鲁卫生与健康杰出青年人才资助项目(鲁卫人才字[2020]3号) （鲁卫人才字[2020]3号）
山东省中医药科技项目(Z-2022098T) （Z-2022098T）
