山东科学2024，Vol.37Issue(2)：29-35,7.DOI:10.3976/j.issn.1002-4026.20240014
网络药理学和斑马鱼模型在中药药效物质及作用机制研究中的应用进展
Advancements in network pharmacology and zebrafish modeling for studying traditional Chinese medicine's effective substances and mechanisms of action
摘要
Abstract
Network pharmacology,which is highly consistent with the holistic and systematic perspectives of traditional Chinese medicine(TCM)with its multiple components and targets,has rapidly developed in the modernization of TCM.Experimental verification is one of the key contents of network pharmacology research.The zebrafish model has a complete system of drug metabolism,as well as a complex in vivo environment and target and pathway regulation mechanisms.Experiments that utilize this model have the advantages of low drug dosage,high throughput,and short cycle time.In recent years,the research mode that combines network pharmacology prediction with experimental validation using the zebrafish model has been widely applied to elucidate the effective substances and mechanisms of action of TCM.This study reviews the progress and development trends in the comprehensive application of network pharmacology and zebrafish modeling,aiming to provide a reference for their application in elucidating the modern scientific implications of the efficacy of TCM.关键词
网络药理学/斑马鱼/中药/药效物质/机制/质量标志物Key words
network pharmacology/zebrafish/traditional Chinese medicine/effective substances/mechanism/quality markers分类
医药卫生引用本文复制引用
刘可春,王勇澄,臧晓涵,夏青,张云,张姗姗,孙晨..网络药理学和斑马鱼模型在中药药效物质及作用机制研究中的应用进展[J].山东科学,2024,37(2):29-35,7.基金项目
山东省重点研发计划(重大科技创新工程)(2021CXGC10507,2022CXGC020515) （重大科技创新工程）
山东省中央引导地方科技发展资金项目(YDZX2022164) （YDZX2022164）
