生物骨科材料与临床研究2024，Vol.21Issue(2)：71-76,6.DOI:10.3969/j.issn.1672-5972.2024.02.015
壳聚糖基可注射水凝胶在骨组织修复再生方面的研究进展
Research progress of chitosan-based injectable hydrogels in bone tissue repair and regeneration
摘要
Abstract
Millions of procedures involving bone grafts and bone substitutes are performed worldwide each year.Traditional bone repair strategies include autograft,allograft,and surgical reconstruction,but they can carry potential risks of donor site morbidity,rejection,risk of disease transmission,and repeated surgery.The need for bone grafts in clinical practice continues to grow due to the increasing number of bone defects caused by trauma,cancer,infection and arthritis.Bone tissue engineering provides promising substitutes in biopharmaceutical applications.Chitosan has good biocompatibility,biodegradability,antibacterial,antioxidant,low toxicity and low cost,which is considered as an important bone repair material in the field of tissue regeneration.Thus,chitosan-based injectable hydrogels can uniformly fill irregular bone defects and have proven to be effective substitutes for autologous bone and dental implants when combined with other polymers or bioactive ingredients.This review focuses on the preparation,physicochemical properties and development status of chitosan-based injectable hydrogels in bone regeneration,and also summarizes the current challenges and future development direction of bone tissue engineering,which will provide a new idea for the development of a new generation of tissue engineering scaffold materials for the treatment of bone defect repair.关键词
壳聚糖/可注射水凝胶/刺激响应性/骨修复/组织再生Key words
Chitosan/Injectable hydrogel/Stimulus responsiveness/Bone repair/Tissue regeneration分类
医药卫生引用本文复制引用
唐国柯,朱亮,刘彦斌,晏美俊,付强,王星..壳聚糖基可注射水凝胶在骨组织修复再生方面的研究进展[J].生物骨科材料与临床研究,2024,21(2):71-76,6.基金项目
上海市长宁区科学技术委员会医疗卫生科研专项课题(CNKW2020Y01) （CNKW2020Y01）
中国博士后科学基金面上项目(2020M683733) （2020M683733）
