上海针灸杂志2024，Vol.43Issue(4)：381-388,8.DOI:10.13460/j.issn.1005-0957.2024.04.0381
针刺联合火龙罐治疗轻中度溃疡性结肠炎的疗效观察
Effect of acupuncture combined with Huo Long cupping on mild and moderate ulcerative colitis
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture combined with Huo Long cupping in the treatment of mild and moderate ulcerative colitis and its influence on serum inflammatory factors,intestinal mucosal barrier function and fecal intestinal flora.Method A total of 120 patients with mild and moderate ulcerative colitis were randomly divided into an observation group and a control group,with 60 cases in each group.The control group was treated with oral Mesalazine tablets,and the observation group was treated with acupuncture combined with Huo Long cupping on the basis of the treatment of the control group.The modified Mayo score of ulcerative colitis,inflammatory bowel disease questionnaire(IBDQ)score and Baron scale score of colonoscopy were observed before and after treatment in the two groups.The serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)],as well as intestinal mucosal barrier function indicators[hypoxia inducible factor-1α(HIF-1α),diamine oxidase(DAO)and endotoxin(ET)]were observed before and after treatment in the two groups.The logarithm of live bacteria of intestinal flora(Enterococcus,Escherichia coli,Lactobacillus and Bifidobacterium)in feces were observed before and after treatment.The clinical efficacy was compared between the two groups.Result The total effective rate of the observation group was 96.6%,which was higher than 85.7%of the control group(P＜0.05).After treatment,the Mayo and Baron scores of the two groups were decreased(P＜0.05),and the IBDQ score was increased(P＜0.05).The above scores in the observation group were better than those in the control group(P＜0.05).After treatment,the levels of serum TNF-α,IL-6,CRP,ET,HIF-1α and DAO in the two groups were decreased(P＜0.05),and those in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of Enterococcus and Escherichia coli in the two groups were decreased(P＜0.05),and the levels of Lactobacillus and Bifidobacterium were increased(P＜0.05).The levels of the above bacteria in the observation group were better than those in the control group(P＜0.05).Conclusion On the basis of oral Mesalazine tablets,acupuncture combined with Huo Long cupping can significantly relieve the clinical symptoms of patients with mild and moderate ulcerative colitis,improve the levels of serum inflammatory factors,improve intestinal mucosal barrier function,and regulate intestinal flora in feces.关键词
针刺疗法/针药并用/拔罐/结肠炎,溃疡性/肠道菌群/炎症因子Key words
Acupuncture therapy/Acupuncture medication combined/Cupping therapy/Colitis,Ulcerative/Gut microbiota/Inflammatory factors分类
中医学引用本文复制引用
千圣楠,高宗跃..针刺联合火龙罐治疗轻中度溃疡性结肠炎的疗效观察[J].上海针灸杂志,2024,43(4):381-388,8.基金项目
河南省中医药科学研究专项课题(2023ZY2103,2022ZY2027) （2023ZY2103,2022ZY2027）
