LFI联合CTP评分对肝硬化病人肝病复合不良事件的预测价值OACSTPCD

Objective:To explore the predictive value of LFI combined with Child-Turcotte-Pugh for complex adverse events in patients with cirrhosis,and to provide evidence for early identification of adverse outcomes and formulation of intervention measures.Methods:This was a prospective cohort study.A total of 259 inpatients diagnosed with cirrhosis in the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University from January to July 2022 were selected.LFI assessment was completed within 48 hours after admission,and they were divided into frailty group and control group according to LFI index.A mean follow-up of 6.33 months was conducted to observe complex adverse events of liver disease,including hepatology-related complications and hepatology-related deaths.Cox proportional risk regression model was used to analyze the influencing factors of liver disease complex adverse events.The area under ROC curve was used to evaluate the predictive value of LFI combined with CTP score and MELD score for liver disease complex adverse events.At the same time,Kaplan-Meier survival analysis was used to study the survival of patients in the two groups.Results:204 cases were included in this study.There were 54 cases(26.5%)of hepatic complex adverse events,including 15 cases(7.4%)of death.A multivariate Cox proportional risk regression model was used,and the results showed that LFI,albumin,nutritional risk,and weekly activity level may be influencing factors for the occurrence of liver disease composite adverse events.The area under the curve(AUC)of LFI combined with CTP score and MELD score to predict complex adverse events of liver disease were 0.85 and 0.83,respectively.Kaplan-Meier survival analysis indicated that the incidence of liver complex adverse events and mortality in the frailty group were significantly higher than those in the control group.Conclusions:Frailty,nutritional risk,low protein level and low activity level are the influencing factors of adverse events in patients with cirrhosis.LFI combined with CTP and MELD score was more effective in predicting complex adverse events of liver disease in patients with cirrhosis.