术后谵妄和血清白细胞介素-6对冠状动脉旁路移植术后病人认知功能障碍的预测作用OACSTPCD

Objective:To investigate the role of postoperative delirium(POD)and serum interleukin-6(IL-6)in predicting postoperative cognitive dysfunction(POCD)in patients undergoing coronary artery bypass grafting(CABG).Methods:187 patients in intensive care unit of cardiac surgery were enrolled by convenience sampling.The cognitive function was measured by the Mini-Mental State Examination.The Logistic regression was used to determine the predictive value of POD and IL-6 to POCD,and areas under the curve(AUC)of the receiver operation characteristic curve was used to evaluate the predictive ability of the predictors to POCD.Results:The incidence of POCD was 37.91%.Multivariate Logistic regression analysis showed that the risk of POCD in POD patients increased by 3.655 times(OR=3.655,95%CI 1.014-13.182).Patients with high IL-6 levels(≥830.50 pg/mL)at the 6 hours after surgery had a 5.042 fold increased risk of developing POCD(OR=5.042,95%CI 1.480-17.178).The predictive power of the two factors was stronger in the elderly than in the non-elderly(P<0.05).Conclusions:POD and high IL-6 level at the 6 hours after surgery are effective indicators for predicting the occurrence of POCD.Healthcare providers should pay more attention to the screening of perioperative risk factors for POCD,and provide targeted interventions.