护理研究2024，Vol.38Issue(7)：1190-1195,6.DOI:10.12102/j.issn.1009-6493.2024.07.009
术后谵妄和血清白细胞介素-6对冠状动脉旁路移植术后病人认知功能障碍的预测作用
Predictive ability of postoperative delirium and serum interleukin-6 on postoperative cognitive dysfunction in patients after coronary artery bypass grafting
摘要
Abstract
Objective:To investigate the role of postoperative delirium(POD)and serum interleukin-6(IL-6)in predicting postoperative cognitive dysfunction(POCD)in patients undergoing coronary artery bypass grafting(CABG).Methods:187 patients in intensive care unit of cardiac surgery were enrolled by convenience sampling.The cognitive function was measured by the Mini-Mental State Examination.The Logistic regression was used to determine the predictive value of POD and IL-6 to POCD,and areas under the curve(AUC)of the receiver operation characteristic curve was used to evaluate the predictive ability of the predictors to POCD.Results:The incidence of POCD was 37.91%.Multivariate Logistic regression analysis showed that the risk of POCD in POD patients increased by 3.655 times(OR=3.655,95%CI 1.014-13.182).Patients with high IL-6 levels(≥830.50 pg/mL)at the 6 hours after surgery had a 5.042 fold increased risk of developing POCD(OR=5.042,95%CI 1.480-17.178).The predictive power of the two factors was stronger in the elderly than in the non-elderly(P<0.05).Conclusions:POD and high IL-6 level at the 6 hours after surgery are effective indicators for predicting the occurrence of POCD.Healthcare providers should pay more attention to the screening of perioperative risk factors for POCD,and provide targeted interventions.关键词
冠状动脉旁路移植术/谵妄/认知功能障碍/白细胞介素-6Key words
coronary artery bypass grafting/delirium/cognitive dysfunction/interleukin-6引用本文复制引用
彭婷婷,邓珣,吴瑛,张山..术后谵妄和血清白细胞介素-6对冠状动脉旁路移植术后病人认知功能障碍的预测作用[J].护理研究,2024,38(7):1190-1195,6.基金项目
北京市教育委员会科研计划项目,编号:KM202310025016 （）
