塔里木大学学报2024，Vol.36Issue(1)：13-21,9.DOI:10.3969/j.issn.1009-0568.2024.01.002
塔克拉玛干沙漠来源产氨基糖苷类次级代谢产物潜力链霉菌的筛选
Screening of Streptomyces with potential for producing secondary metabolites of aminoglycosides from the Taklamakan Desert
摘要
Abstract
Aminoglycosides are a class of broad-spectrum antibacterial drugs,which are mainly isolated from Streptomyces and Mi-cromonospora;this type of drug can treat a variety of infectious diseases and crop rot,etc,which plays an important role in biomedi-cine,agricultural and other fields.In order to provide germplasm resources and enrich aminoglycoside compounds for the discovery and excavation of new aminoglycoside natural products.Through the combination of"gene-activity-chemistry"screening method,TRM71140 and TRM94015 with aminoglycoside production potential were selected from 132 Streptomyces.The spectinomycin signal was detected from the TRM94015 fermentation product by mass spectrometry,which enriched the potential strains of aminoglycoside compounds.关键词
沙漠链霉菌/次级代谢产物挖掘/氨基糖苷类药物Key words
Streptomyces deserticus/secondary metabolite mining/aminoglycosides分类
生物科学引用本文复制引用
张嘉馨,骆新荣,刘占文,高佳敏,罗晓霞,张利莉..塔克拉玛干沙漠来源产氨基糖苷类次级代谢产物潜力链霉菌的筛选[J].塔里木大学学报,2024,36(1):13-21,9.基金项目
国家自然科学基金-新疆联合基金重点项目(U1703236) （U1703236）
