同位素2024，Vol.37Issue(2)：195-201,7.DOI:10.7538/tws.2024.37.02.0195
氮杂环卡宾介导的协同芳香亲核取代在18F标记反应中的应用进展
Application Progress of N-Heterocyclic Carbene-mediated Concerted Nucleophilic Aromatic Substitution in 18F Labeling Reaction
摘要
Abstract
Concerted nucleophilic aromatic(CSNAr)substitution reactions play an important role in nuclear chemistry synthesis,and are now used to develop positron radiotracers.Compared with the traditional nucleophilic aromatic substitution reaction,the advantages of this substitution reaction lie in the fact that the range of substrates is not limited to electron-deficient aromatic compounds,and the radiolabeled products can be easily separated from the reaction system.In this paper,the mechanism of concerted nucleophilic aromatic substitution reaction was first elaborated,and the CSNAr reaction mediated by 1,3-bis(2,6-diisopropylphenyl)2-chloroimidazolium chloride(SIPr·HCl)and its application progress in the preparation of positron nuclide-labeled radiotracer were focused.We emphasized the importance of concerted nucleophilic aromatic substitution reactions for synthesizing 18F radiotracers,summarized existing shortcomings,and prospectd future application prospects.关键词
协同芳香亲核取代/18F/SIPr·HClKey words
CSNAr/18F/SIPr·HCl分类
能源科技引用本文复制引用
王慧,单崇玮,何玉林..氮杂环卡宾介导的协同芳香亲核取代在18F标记反应中的应用进展[J].同位素,2024,37(2):195-201,7.基金项目
国家自然科学基金(82060323) （82060323）
内蒙古自治区高等学校"青年科技英才支持计划"项目(NJYT22003) （NJYT22003）
内蒙古自治区自然科学基金(2022MS08003) （2022MS08003）
