生殖医学杂志2024，Vol.33Issue(4)：540-545,6.DOI:10.3969/j.issn.1004-3845.2024.04.020
脑源性神经营养因子和神经营养因子-5在女性生殖内分泌领域的研究进展
Research progress of brain derived neurotrophic factor and neurotrophin 5 in female reproductive endocrine system
摘要
Abstract
Brain derived neurotrophic factor(BDNF)and neurotrophin-5(NT-5),which act on the same receptors-TrkB and p75NTR,are members of neurotrophin family and a kind of secretory polypeptides which are secreted by the target tissue innervated by nerves.BDNF and NT-5 are widely expressed in the ovary and play important roles in multiple reproductive physiological activities,such as follicular assembly and development,oocyte maturation,ovulation and steroidogenesis in granulosa and theca cells.Infertility is a reproductive disorder caused by multiple etiology.Among infertile patients,there is an abnormal secretion of BDNF and NT-5 in the ovary.Therefore,understanding the research progress of BDNF and NT-5 in female reproductive endocrine system may provide new directions for the treatment of infertility and new indicators for predicting pregnancy outcomes of assisted reproduction.关键词
脑源性神经营养因子/神经营养因子-5/酪氨酸激酶受体B/不孕症Key words
Brain derived neurotrophic factor/Neurotrophin-5/Tyrosine kinase receptor B/Infertility引用本文复制引用
娄艳茹,刘晨虹,严杰,杨蕊..脑源性神经营养因子和神经营养因子-5在女性生殖内分泌领域的研究进展[J].生殖医学杂志,2024,33(4):540-545,6.基金项目
国家自然科学基金项目(82171632,T2293764) （82171632,T2293764）
国家重点研发计划课题(2021YFC2700605,2022YFC2703000) （2021YFC2700605,2022YFC2703000）
