脑源性神经营养因子和神经营养因子-5在女性生殖内分泌领域的研究进展OACSTPCD
Research progress of brain derived neurotrophic factor and neurotrophin 5 in female reproductive endocrine system
脑源性神经营养因子(BDNF)和神经营养因子-5(NT-5)属于神经营养因子家族,是一类由神经支配的靶组织分泌的分泌型多肽,两者通过作用于相同的受体发挥作用.BDNF和NT-5在卵巢表达广泛,发挥着促进卵泡组装和发育、卵母细胞成熟、排卵、调节颗粒细胞和膜细胞类固醇激素分泌等多种生理作用.不孕症是由多种病因导致的一种生育障碍状态,不孕症患者卵巢局部的BDNF和NT-5存在异常分泌情况.因此,了解BDNF和NT-5在女性生殖内分泌领域的研究进展,可能为不孕症治疗提供新方向,为辅助生殖结局的预测提供新指标.
Brain derived neurotrophic factor(BDNF)and neurotrophin-5(NT-5),which act on the same receptors-TrkB and p75NTR,are members of neurotrophin family and a kind of secretory polypeptides which are secreted by the target tissue innervated by nerves.BDNF and NT-5 are widely expressed in the ovary and play important roles in multiple reproductive physiological activities,such as follicular assembly and development,oocyte maturation,ovulation and steroidogenesis in granulosa and theca cells.Infertility is a reproductive disorder caused by multiple etiology.Among infertile patients,there is an abnormal secretion of BDNF and NT-5 in the ovary.Therefore,understanding the research progress of BDNF and NT-5 in female reproductive endocrine system may provide new directions for the treatment of infertility and new indicators for predicting pregnancy outcomes of assisted reproduction.
娄艳茹;刘晨虹;严杰;杨蕊
北京大学第三医院妇产科生殖医学中心,女性生育力促进全国重点实验室国家妇产疾病临床医学研究中心辅助生殖教育部重点实验室北京市生殖内分泌与辅助生殖技术重点实验室,北京 100191
脑源性神经营养因子神经营养因子-5酪氨酸激酶受体B不孕症
Brain derived neurotrophic factorNeurotrophin-5Tyrosine kinase receptor BInfertility
《生殖医学杂志》 2024 (004)
神经营养因子NT-5调节脂蛋白受体LDLR/SCARB1表达参与肥胖型PCOS不孕症患者卵成熟障碍的机制研究
540-545 / 6
国家自然科学基金项目(82171632,T2293764);国家重点研发计划课题(2021YFC2700605,2022YFC2703000)
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