同位素2024，Vol.37Issue(2)：106-125,20.DOI:10.7538/tws.2024.37.02.0106
放射性标记小分子抑制剂用作靶向FAP肿瘤显像剂的现状与展望
Status and Prospect of Radiolabeled Small Molecule Inhibitors as Tumor Imaging Agents Targeting FAP
摘要
Abstract
Fibroblast activation protein(FAP)exists in tumor stromal fibroblasts and is a significant target for tumor diagnosis and treatment recently.Among the radioactive FAP-targeted tumor imaging agents,small-molecule tracers have received the most extensive attention.This paper elucidates the core structure of FAP-targeted small molecule drugs,categorizes the various design approaches employed for the development of novel small molecule imaging agents targeting FAP,up until December 2023.Additionally,a comprehensive analysis of FAP-targeted PET imaging agents and SPECT imaging agents with excellent biological performance or innovative structure is conducted.The structures and design concepts of these agents are carefully examined and summarized,with the aim of making valuable contributions to clinical diagnosis and treatment.关键词
FAP/小分子药物/放射性肿瘤显像剂Key words
FAP/small molecule drug/tumor imaging agent分类
能源科技引用本文复制引用
韩沛雯,阮晴,张俊波..放射性标记小分子抑制剂用作靶向FAP肿瘤显像剂的现状与展望[J].同位素,2024,37(2):106-125,20.基金项目
国家自然科学基金(22076013,22276015) （22076013,22276015）
北京市自然科学基金(2232010) （2232010）
中国博士后科学基金(2022M720464) （2022M720464）
北京市科技新星计划交叉合作课题(20230484470) （20230484470）
