现代妇产科进展2024，Vol.33Issue(4)：249-254,6.DOI:10.13283/j.cnki.xdfckjz.2024.04.001
基于SEER数据库的育龄期女性Ⅰ期卵巢透明细胞癌不同治疗方式生存率分析和术后生存预测模型构建
Selection of treatment and construction of postoperative prediction model for Stage Ⅰ o-varian clear cell carcinoma in women of childbearing age
摘要
Abstract
Objective:To investigate the long-term prognosis of patients with stage Ⅰ o-varian clear cell carcinoma(OCCC),and constructed a nomogram to predict the prognosis of patients with OCCC at stage Ⅰ after surgery.Methods:Patients with a histological diagnosis of o-varian clear cell carcinoma between 2010 and 2019 were identified from the SEER database for the study.Kaplan-Meier were used to evaluate the effect of radical surgery with or without chemotherapy on overall survival and cancer-specific survival.Cox proportional risk models were used to assess the association of clinicopathological factors with overall survival(OS)and canc-er-specific survival(CSS).Create a nomogram using parameters that were significantly relevant to OS and CSS,and evaluate the performance of the nomogram with internal validation.Result:A total of 824 patients with OCCC were included,and 173 patients received hysterectomy(HRT)alone,adjuvant chemotherapy after hysterectomy(HRT+CT)in 430 cases,54 patients underwent the operation of preserving uterus(NHRT).167 cases selected NHRT+CT.Patients receiving NHRTS had the best prognosis for CSS and OS compared to the other three(P = 0.0077,0.0078).Patients treated with NHRT alone had better survival rates than those treated with NHRT+CT(CSS,P=0.0052;OS,P=0.0062).Multivariate Cox regression analysis con-firmed that age,marital status,tumor stage and treatment plan were independent prognostic fac-tors of CSS and OS.According to the results,the postoperative prognosis histogram of stage Ⅰ OCCC patients was established,and the area AUC under the ROC curve of CSS and OS histo-gram was 0.7 and 0.701,respectively.The DCA results of the column graph showed that the prediction model was beneficial in clinic,and the standard curve was in good agreement with the observed values.Conclusions:Fertility-sparing surgery may be an alternative treatment option for women of childbearing age with stage Ⅰ OCCC.Further research is needed to determine the role of adjuvant chemotherapy in patients with stage Ⅰ OCCC.The constructed column diagram has good survival prediction and clinical application value for patients with stage Ⅰ OCCC after operation.关键词
卵巢透明细胞癌/SEER数据库/治疗方式/列线图/生存率Key words
Ovarian clear cell carcinoma/SEER database/Treatment/Nomogram/O-verall survival分类
医药卫生引用本文复制引用
张莎,王路路,刘楚琦,雷冬梅,郭瑞霞..基于SEER数据库的育龄期女性Ⅰ期卵巢透明细胞癌不同治疗方式生存率分析和术后生存预测模型构建[J].现代妇产科进展,2024,33(4):249-254,6.基金项目
国家自然科学基金(联合基金项目)(No:U2004117) （联合基金项目）
