现代妇产科进展2024，Vol.33Issue(4)：255-263,9.DOI:10.13283/j.cnki.xdfckjz.2024.04.002
子宫内膜癌ProMisE分子分型与临床病理特征及预后的相关性分析
Correlation analysis of ProMisE molecular classification with clinical pathological fea-tures and prognosis in endometrial cancer
摘要
Abstract
Objective:To explore the correlation between ProMisE molecular classifica-tion and clinical pathological features and its impact on the prognosis of endometrial cancer pa-tients.Methods:Retrospectively analyze clinical and pathological data of 81 patients with endo-metrial cancer undergoing surgery and perform ProMisE molecular classification of them.The correlations of ProMisE molecular classification with clinicopathological characteristics were ex-amined by non-parametric tests.Cross analysis was conducted on the consistency between ProM-isE molecular typing and 2016 ESMO risk stratification using Kappa consistency test.The Kap-lan-Meier method was used to plot survival curves,univariate and multivariate factor Cox regres-sion analysis were used to explore the risk factors affecting the prognosis of patients with endom-etrial cancer.Results:There was no statistically significant correlation between ProMisE molec-ular classification and various clinical pathological factors.The consistency between ProMisE molecular classification and ESMO risk stratification was poor(Kappa=0.005,P=0.922).Multivariate Cox regression analysis showed that positive ascitic cytology(HR = 19.471,P = 0.001)and cervical interstitial invasion(HR=9.662,P=0.032)were independent prognostic factors for decreased PFS,and positive ascitic cytology(HR=20.641,P=0.012)was also an independent prognostic factor for OS.ESMO risk stratification and ESGO-ESTRO-ESP risk strat-ification model has a better predictive ability for PFS compared to ProMisE molecular classifica-tion(P<0.05).Conclusion:The consistency between ProMisE molecular classification and ES-MO risk stratification is poor.The ESGO-ESTRO-ESP prognostic stratification model,which combines molecular classification and clinical pathological parameters,has a stronger ability to predict patient PFS.Positive ascitic cytology is an independent prognostic factor affecting PFS and OS in patients.关键词
子宫内膜癌/ProMisE分子分型/ESMO风险分层/治疗/预后Key words
Endometrial Cancer/ProMisE Molecular classification/ESMO Risk Strati-fication/Treatment/Prognosis分类
医药卫生引用本文复制引用
刘红,罗敏,彭春蓉,樊英,何静,罗古坡,王登凤,张国楠..子宫内膜癌ProMisE分子分型与临床病理特征及预后的相关性分析[J].现代妇产科进展,2024,33(4):255-263,9.基金项目
北京康华中西医发展基金会2021年度第一批"妇科肿瘤专项研究基金"项目(No:KH-2021-LLZX-009) （No:KH-2021-LLZX-009）
