信阳师范学院学报（自然科学版）2024，Vol.37Issue(2)：216-221,6.DOI:10.3969/j.issn.1003-0972.2024.02.013
基于二房室模型的个体化给药方案设计的建模与仿真
Modeling and Simulation of Individualized Drug Delivery Scheme Design Based on Two-compartment Model
摘要
Abstract
The impulsive differential equation was used to study the changes of blood drug concentration for the two-atrioventricular model under multiple intravenous administration.The blood drug concentration changed periodically under the stable condition.Based on the drug safety window,the specific flow and algorithm steps of drug administration plan design were discussed.Further,combined with the blood drug concentration data of 24 tumor patients measured by experiment at different time series after a single intravenous injection of methotrexate,the pharmacokinetic specific parameters of 24 patients were estimated by the method of nonlinear regression analysis.The similarities and differences among patients were studied by using the patient-specific parameter values.Finally,based on the specific parameter values of different patients,the individualized drug administration plan was given.关键词
二房室模型/静脉注射/个体化差异/给药方案设计Key words
two-compartment model/intravenous injection/individualized difference/dosage regimen design分类
数理科学引用本文复制引用
关英子,刘畅,张菲,庞留勇,王露..基于二房室模型的个体化给药方案设计的建模与仿真[J].信阳师范学院学报（自然科学版）,2024,37(2):216-221,6.基金项目
国家自然科学基金项目(11701207,12171193) （11701207,12171193）
河南省科技计划项目(232102310200,242102110145) （232102310200,242102110145）
河南省高等学校重点科研项目(23A110019) （23A110019）
2023年河南省专业学位研究生精品教学案例(YJS2023AL090) （YJS2023AL090）
