细菌纤维素/羟基磷灰石@聚醚砜骨膜支架的制备及其性能研究OA

Rebuilding the periosteum's structure and function is crucial for the healing of large-scale bone defects because the periosteum serves as a source of nutrients and is the central location of intramembranous osteogenesis during the healing of bone.Herien,in order to mimic the composition and functionality of the natural periosteum,mixed polyethersulfone(PES)and HAp to prepare HAp@PES electrospun fiber membrane(HPES)by electrospinning and then composited them with bacterial cellulose(BC)by the membrane-liquid interface culture method to obtain the BC/HAp@PES(BC/HPES)scaffold with a micron-nano fibrous structure.Scanning electron microscopy(SEM)analysis confirms that the scaffold exhibits a staggered distribution of micron-nano fibers,and HAp was successfully compounded on the micronfibers.The prepared scaffold displays good mechanical properties.Subsequent research revealed that osteoblasts showed good proliferation and spreading ability on the surface of the scaffold,and the scaffold also had good osteogenic differentiation induction ability.Thus,this periosteum scaffold with biomimetic micro-nano fiber structure and HAp-loaded is expected to be used in the field of large-scale bone defect repair.