功能化细菌纤维素纳米晶复合聚氨酯医用抗菌涂层的制备及性能研究OA
Preparation and Properties of Functional Bacterial Cellulose Nanocrystalline Polyurethane Composite Antibacterial Coating for Medical Purposes
植入医疗器械的感染是临床治疗的难题之一,因此研究具有长效稳定抗菌效果的医用涂层对于医疗植入器械领域十分重要.本研究使用细菌纤维素膜片,通过粉碎―氧化法制备氧化改性细菌纤维素纳米晶体,并化学接枝阳离子化合物双胍制备获得新型纳米抗菌材料 NBC-BG,最后与聚氨酯(PU)进行复合制备了 PU-NBC-BG 医用抗菌涂层.通过多种材料表征手段,研究了不同比例添加下涂层的结构性能变化,同时通过抗菌实验证明了 PU-NBC-BG 涂层具有优良且稳定的抗菌性能以及抗生物膜效果,在医疗器械领域具有很好的前景.
The infection of medical implants is one of the difficult problems in clinical treatment.Therefore,it is crucial to conduct research on medical coatings that exhibit long-term stable antibacterial effects.In this study,oxidized modified bacterial cellulose nanocrystals were prepared using the comminution-oxidation method,and a cationic compound called biguanide was chemically grafted onto them to create a new nanometer-sized antibacterial material known as NBC-BG.By combining NBC-BG with polyurethane(PU),a medical antibacterial coating named PU-NBC-BG was developed.The structural properties of these coatings with varying proportions were investigated through various material characterization techniques.Furthermore,the antibacterial experiment demonstrated that the PU-NBC-BG coating exhibits excellent and enduring antibacterial properties as well as an effective anti-biofilm effect,making it highly promising for application in the field of medical devices.
杨惠仪;张栗杨;丁蒙;贺玮;谢亚杰;乔堃;郑裕东
北京科技大学 材料科学与工程学院,北京 100083北京中杰瑞康科技有限公司,北京 100094
化学工程
细菌纤维素纳米晶双胍长效抗菌医用涂层
bacterial cellulose nanocrystalsbiguanidelong-acting antibacterialmedical coating
《纤维素科学与技术》 2024 (001)
28-38 / 11
国家自然科学基金(52273119,51973018);北京市科委项目(Z191100002019017);北京市自然科学基金(2222067,L222035);北京科技大学 2022年度研究生教育教学改革面上项目(2023JGC004).
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