眼科新进展2024，Vol.44Issue(4)：282-286,5.DOI:10.13389/j.cnki.rao.2024.0055
不同病程非动脉炎性前部缺血性视神经病变患者视功能与视网膜结构的关系
Relationship between visual function and retinal structure in non-arteritic anterior ischemic optic neuropathy of different courses
摘要
Abstract
Objective To observe the changes in visual function and retinal structure in patients with non-arteritic anterior ischemic optic neuropathy(NAION)at different stages and analyze the correlation between visual function and structural indicators.Methods A retrospective study was conducted on 33 patients(33 eyes)with NAION presented within 3 weeks of onset.Changes in visual function[best corrected visual acuity(BCVA),visual field mean deviation(MD),pattern standard deviation(PSD),and visual field index(VFI)]and retinal structure[peripapillary retinal nerve fi-ber layer(pRNFL)]thickness,macular ganglion cell complex(mGCC)thickness and loss volume,and radial peripapillary capillary(RPC)density)were analyzed from 4 to 12 weeks of onset and over 12 weeks of onset.The change features of and correlation between visual function indicators and structural indicators were analyzed.Results The BCVA of NAION eyes exhibited significant improvement with disease progression(P=0.021),with a statistically significant difference be-tween onset＞12 weeks and onset≤3 weeks(P=0.020)and no statistically significant difference between onset≤3 weeks and onset from 4 to 12 weeks or between onset from 4 to 12 weeks and onset＞12 weeks(P=0.158 and 0.100).There were no significant differences in MD,PSD and VFI across different stages of NAION(P=0.419,0.767 and 0.134).The pRNFL thickness(average,superior,and inferior),RPC density(average,superior,and inferior),and mGCC thick-ness(average,superior,and inferior)significantly decreased with disease progression(all P＜0.001),while focal loss volume(FLV)and global loss volume(GLV)of mGCC significantly increased with disease progression(both P＜0.001).The differences in these indicators above among each stage were statistically significant(all P＜0.05).Correlation analysis revealed that the BCVA demonstrated positive correlations with mGCC thickness(average and inferior)and RPC density(average and inferior)(all P＜0.05).Conversely,it exhibited negative correlations with FLV and GLV(both P＜0.05).There were no correlations between BCVA and pRNFL thickness(average,superior,and inferior),superior mGCC thick-ness,and superior RPC density(all P＞0.05).MD and VFI showed positive correlations with mGCC thickness(average and inferior)and RPC density(average,superior,and inferior)(all P≤0.001)and negative correlations with GLV(both P＜0.001),but no correlations with pRNFL thickness(average,superior,and inferior),superior mGCC thickness,and FLV(all P＞0.05).PSD showed no correlations with pRNFL thickness(average,superior,and inferior),mGCC thickness(average,superior,and inferior),FLV,GLV,and RPC density(average,superior,and inferior)(allP＞0.05).Conclu-sion The changes in visual acuity and visual field with the progression of NAION are associated with changes in mGCC thickness and RPC density,but not correlated with changes in pRNFL thickness.This suggests that visual function and reti-nal structural changes do not occur synchronously.关键词
视神经病变/缺血性/视功能/体层摄影术Key words
optic neuropathy/ischemic/visual function/tomography分类
医药卫生引用本文复制引用
刘子嘉,林媛媛,宫媛媛..不同病程非动脉炎性前部缺血性视神经病变患者视功能与视网膜结构的关系[J].眼科新进展,2024,44(4):282-286,5.基金项目
国家重点研发计划资助项目(编号:2019YFC0840607) （编号:2019YFC0840607）
上海市科学技术委员会科研计划项目(编号:19401932700) （编号:19401932700）
上海市第一人民医院临床研究创新团队建设项目(编号:CTCCR-2018BP04) （编号:CTCCR-2018BP04）
