针刺研究2024，Vol.49Issue(4)：403-408,433,7.DOI:10.13702/j.1000-0607.20221262
从耳迷走神经探讨耳穴治疗偏头痛的可能机制
Possible mechanisms of auricular acupoint stimulation in the treatment of migraine by activating auricular vagus nerve
摘要
Abstract
Under the guidance of traditional Chinese medicine theory,the clinical research of auricular acupoint stimulation in the treatment of migraine has gained a lot,and the curative efficacy is definite,but its mechanism remains unclear.In the present paper,we discussed the efficacy of auricular acupoint stimulation including"transcutaneous auricular vagus nerve stimulation"(taVNS)in the treatment of migraine in recent years.Through bibliometric analysis,we screened out top 10 auricular acupoints(Shenmen[TF4],Pizhixia[AT4],Jiaogan[AH6a],Gan[CO12],Yidan[CO11],Neifenmi[CO18],Shen[CO10],Nie[AT2],Zhen[AT3]and E[AT1])which were the most frequently used for migraine.Majority of these auricular acupoints just distributed in the region innervated by auricular vagus nerve.Thus,we thought that the analgesic effect of needling these auricular acupoints for migraine was produced by triggering the auricular vagus nerve,and concluded that the central mechanism underlying induction of analgesic effect by activating auricular vagus nerve may be achieved by activating the descending pain regulation pathway of the locus coeruleus nucleus and dorsal raphe nucleus.In addition,taVNS-induced 1)regulation of the activities of brain's default network and pain matrix,2)activation of the cortical descending pain regulation pathway,and 3)inhibition of the neuroinflammatory response may also contribute to its ameliorating effect of migraine.This paper may provide ideas for the future research on the mechanism of auricular acupoint treatment of migraine.关键词
耳穴/偏头痛/经皮耳迷走神经刺激/中枢机制Key words
Auricular acupoints/Migraine/Transcutaneous auricular vagus nerve stimulation(taVNS)/Central mechanism引用本文复制引用
朱浩瀚,荣培晶,陈瑜,宋醒恪,王俊英..从耳迷走神经探讨耳穴治疗偏头痛的可能机制[J].针刺研究,2024,49(4):403-408,433,7.基金项目
国家自然科学基金面上项目(No.82174220) （No.82174220）
中央级公益性科研院所基本科研业务费专项资金资助项目(No.ZZ13-YQ-62) （No.ZZ13-YQ-62）
