中国临床药理学杂志2024，Vol.40Issue(7)：1059-1062,4.DOI:10.13699/j.cnki.1001-6821.2024.07.026
抗结核药物的药品不良反应自动监测研究及其影响因素分析
Automatic monitoring of adverse drug reaction of anti-tuberculosis and analysis of influencing factors
摘要
Abstract
Objective To provide reference for clinical rational drug use,the adverse drug reaction(ADR)automatic monitoring system was used to monitor ADR in patients treated with first-line anti-tuberculosis drugs.Methods A total of 1 147 tuberculosis patients hospitalized in the infection department of our hospital from 2019 to 2022 were selected to monitor the occurrence of ADR during the hospitalization.Univariate and multivariate analysis were used to study the risk factors affecting the incidence of ADR.Results After systematic screening and pharmacist review,a total of 598 cases of ADR related to first-line anti-tuberculosis drugs were found,with an incidence of 52.14％.ADR mainly affects the endocrine system,digestive system,and hepatobiliary system.The incidence of ADR in oral isoniazid is higher than that in intravenous drip and nebulization routes.The results of multivariate regression analysis showed that women and a history of hepatitis were independent risk factors for the occurrence of ADR(all P＜0.05).Conclusion The incidence of ADR with anti-tuberculosis drugs is high.Women and patients with a history of hepatitis are high-risk groups for adverse drug reactions to anti-tuberculosis drugs.In clinical,safer drugs should be selected for such patients,and the occurrence of ADR should be closely monitored to reduce the impact of ADR on the treatment process.关键词
一线抗结核药物/结核病/自动监测系统/药品不良反应/影响因素Key words
first-line anti-tuberculosis drug/tuberculosis/automatic monitoring system/adverse drug reaction/influencing factor分类
药学引用本文复制引用
张凯,路晓钦,董志..抗结核药物的药品不良反应自动监测研究及其影响因素分析[J].中国临床药理学杂志,2024,40(7):1059-1062,4.基金项目
重庆市技术创新与应用发展专项基金资助项目(cstc2019jscx-msxmX0309) （cstc2019jscx-msxmX0309）
