中国全科医学2024，Vol.27Issue(21)：2665-2671,7.DOI:10.12114/j.issn.1007-9572.2023.0069
肠道菌群在脓毒症相关性肝损伤发病与治疗中的作用研究进展
Research Progress on the Role of Gut Microbiota in the Pathogenesis and Treatment of Sepsis-associated Liver Injury
摘要
Abstract
Sepsis is characterized by a dysregulation of immune response to infection,leading to life-threatening organ dysfunction.Sepsis-associated liver injury(SALI)is considered an independent risk factor for predicting death in the intensive care unit(ICU).With the increasing number of studies on the gut-liver axis in recent years,the close linkage of gut microbiota and liver diseases has been gradually revealed.Dysbiosis of gut microbiota has been shown to induce SALI through the mitogen-activated protein kinase/nuclear transcription factor κB(MAPK/NF-κB)signaling pathway and damage to the intestinal barrier.Meanwhile,fecal microbiota transplantation(FMT)and the application of probiotics have great potential in the treatment of SALI.This paper reviews the relevant research progress in recent years both at home and abroad,in order to provide new insights into the pathogenesis and treatment of SALI.关键词
胃肠道微生物组/肠道菌群/脓毒症/肝损伤/粪便微生物移植/益生菌/综述Key words
Gastrointestinal microbiome/Gut microbiota/Sepsis/Liver injury/FMT/Probiotics/Review分类
基础医学引用本文复制引用
陈文胜,刘文明..肠道菌群在脓毒症相关性肝损伤发病与治疗中的作用研究进展[J].中国全科医学,2024,27(21):2665-2671,7.基金项目
吴阶平医学基金会临床科研专项资助基金(320.6750.2022-02-20) （320.6750.2022-02-20）
