中国临床药理学与治疗学2024，Vol.29Issue(5)：501-511,11.DOI:10.12092/j.issn.1009-2501.2024.05.004
PI3K/Akt信号通路调控子宫内膜异位症及中药干预作用研究进展
Research progress on the regulation of endometriosis by PI3K/Akt signaling pathway and the intervention effect of traditional Chinese medicine
摘要
Abstract
Endometriosis(Endometriosis,EMs)is a disease caused by abnormal colonization of the endometrial stroma or glands to sites other than the coated mucosa of the uterine cavity.Phospho-lipid inositol 3 kinase(phosphoinositide 3-kinase,PI3K)/protein kinase B(protein kinase B,Akt)sig-naling pathway is involved in the process of focal blood vessel formation,cell autophagic apoptosis,migration and invasion,and is one of the classic pathways regulating the pathological characteris-tics of EMs.The characteristics of multi-compo-nent,multi-target and multi-pathway of TCM have significant advantages in the treatment of EMs.Some TCM active components and TCM com-pounds can interfere with the PI3K/Akt signaling pathway,thus inhibiting the treatment of endome-triotic tissues,reducing pain and alleviating fibrotic lesions.By explaining the connection between the key targets of PI3K/Akt signaling pathway and EMs,this paper summarizes and summarizes the re-search status of EMs by regulating PI3K/Akt signal pathway in home and abroad,aiming to provide a new perspective and idea for the use of traditional Chinese medicine and compound to treat EMs.关键词
子宫内膜异位症/PI3K/Akt信号通路/中药/经典方剂Key words
endometriosis/phosphoinositide 3-kinase/protein kinase B signaling pathway/tradi-tional Chinese medicine/classic formula分类
医药卫生引用本文复制引用
李泉洋,郝亚芳,吴国泰,王瑞琼..PI3K/Akt信号通路调控子宫内膜异位症及中药干预作用研究进展[J].中国临床药理学与治疗学,2024,29(5):501-511,11.基金项目
国家自然科学基金地区基金资助项目(81660653) （81660653）
甘肃省青年博士基金项目(2021QB-074) （2021QB-074）
甘肃省自然科学基金项目(22JR5RA588) （22JR5RA588）
甘肃省优秀研究生"创新之星"项目(2022CXZX-761) （2022CXZX-761）
