中国临床药理学与治疗学2024，Vol.29Issue(5)：527-534,8.DOI:10.12092/j.issn.1009-2501.2024.05.007
两种地诺孕素治疗子宫内膜异位症的临床疗效及不良反应对比
Comparison of clinical effectiveness and safety between generic and branded dienogest tablets in the treatment of endometriosis
摘要
Abstract
AIM:To evaluate the clinical effective-ness and safety of generic and branded dienogest in the treatment of endometriosis.so as to provide the basis for clinical use of dienogest.MEHTODS:The data of patients admitted to Third Affiliated Hospital of Zhengzhou University from August 2022 to August 2023 who received dienogest(2 mg/d,orally,for 6 months)for treatment of endometrio-sis were collected.The clinical efficacy and adverse reactions of generic drugs and original drugs in the treatment of endometriosis-related pain were com-pared through follow-up surveys of the two groups of patients at 3 months and 6 months respectively.RESULTS:There was highly significant reduction in pelvic pain in both groups with mean of similar in generic group(34.0±3.0)mm and branded group(34.5±3.9)mm.The most frequent drug-related ad-verse effects in generic dienogest was vaginal bleeding(93%)which was no statistical difference with branded dienogest(90%).CONCLUSION:The generic and branded dienogest have the same clini-cal effectiveness and similar safety.关键词
地诺孕素/仿制药/原研药/子宫内膜异位症Key words
dienogest/generic drugs/branded drugs/endometriosis分类
医药卫生引用本文复制引用
刘倩,张家宁,张双,刘青蓝,张保寅,孙楠..两种地诺孕素治疗子宫内膜异位症的临床疗效及不良反应对比[J].中国临床药理学与治疗学,2024,29(5):527-534,8.基金项目
河南省医学科技攻关计划(联合共建)项目(LHGJ20190402) （联合共建）
