中国医科大学学报2024，Vol.53Issue(3)：240-245,6.DOI:10.12007/j.issn.0258-4646.2024.03.009
基于血清CA50、TSGF、TPA的中晚期乳腺癌放化疗敏感性列线图预测模型的建立与评价
Establishment and evaluation of the model for predicting the sensitivity to radiochemotherapy in patients with middle-and advanced-stage breast cancer based on serum CA50,TSGF,and TPA
摘要
Abstract
Objective To evaluate the predictive value of serum carbohydrate antigen 50(CA50),tumor specific growth factor(TSGF),and tissue polypeptide antigen(TPA)levels for sensitivity to radiochemotherapy in patients with middle-and advanced-stage breast cancer using a nomogram model.Methods Eighty-two patients with middle-and advanced-stage breast cancer were selected as the study sub-jects.All patients received paclitaxel chemotherapy combined with radiotherapy and were divided into sensitive(n= 57)and insensitive(n= 25)groups according to the Response Evaluation Criteria in Solid Tumors.The general information of the patients,serum expression of CA50,TSGF,and TPA,and their differences before and after treatment were recorded.A nomogram model was constructed,and cali-bration curves,receiver operating characteristic(ROC)curves,and decision curves were used to evaluate the predictive power and clinical utility of the nomogram model.Results Significant differences were observed in tumor diameter,vascular invasion,TNM stage,lymph node metastasis,and degree of differentiation between the two groups(P＜0.05).Compared to those in the sensitive group,the serum expression of CA50,TSGF,and TPA after treatment was higher,and the difference in CA50,TSGF,and TPA was smaller in the insensitive group(P＜0.05).Three predictive variables were identified in the LASSO regression:differences in CA50,TSGF,and TPA.The logistic regression results showed that differences in CA50,TSGF,and TPA influenced sensitivity to radiochemotherapy in middle-and advanced-stage breast cancer(P＜0.05).A nomogram model was constructed using differences in CA50,TSGF,and TPA.Calibration,ROC,and decision curves showed the model's good predictive accuracy and clinical utility.Conclusion Serum expression of CA50,TSGF,and TPA is high in patients with middle-and advanced-stage breast cancer who are insensitive to radiochemotherapy,and differences in CA50,TSGF,and TPA affect their sensitivity to radiochemotherapy.The nomogram model had good predictive value and clinical utility.关键词
糖类抗原50/肿瘤特异性生长因子/组织多肽抗原/中晚期乳腺癌/放化疗敏感性/列线图模型Key words
carbohydrate antigen 50/tumor specific growth factor/tissue polypeptide antigen/middle-and advanced-stage breast cancer/sensitivity to radiochemotherapy/nomogram model分类
医药卫生引用本文复制引用
陈国华,张浩宇,韩升波,何建鑫..基于血清CA50、TSGF、TPA的中晚期乳腺癌放化疗敏感性列线图预测模型的建立与评价[J].中国医科大学学报,2024,53(3):240-245,6.基金项目
河南省医学科技攻关计划(联合共建)项目(LHGJ20190514) （联合共建）
